| 低强度超声对激素诱导的兔高眼压的作用 |
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| 引用本文： | 陈琳,刘苏. 低强度超声对激素诱导的兔高眼压的作用[J]. 基础医学与临床, 2007, 27(3): 284-287 |
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| 作者姓名： | 陈琳 刘苏 |
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| 作者单位： | 重庆医科大学,儿童医院,眼科,重庆,400010;重庆医科大学,第二附属医院,眼科,重庆,400010 |
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| 基金项目： | 重庆市卫生局科研基金(0301) |
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| 摘 要： | 目的探讨低强度超声对兔激素性高眼压的影响及其机制。方法采用超声直接接触法对兔激素性高眼压连续治疗5d并监测眼压。观察眼压、小梁组织的HE染色,透射电镜、免疫组化法及图像分析观察小梁外基质层黏连蛋白、纤维连接蛋白和胶原Ⅰ的变化。结果低强度超声处理后眼压显著下降,小梁网间隙增大,胶原I、层黏连蛋白及纤维连接蛋白的表达低于对照组。结论低强度超声所致眼压降低与小梁组织超微结构改变及超声机械震荡等使异常增多的小梁外基质减少有关。
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| 关 键 词： | 动物模型 激素性高眼压 超声疗法 |
| 文章编号： | 1001-6325(2007)03-0284-04 |
| 收稿时间： | 2005-06-01 |
| 修稿时间： | 2005-06-17 |
Effect of low intensity ultrasound on dexamethasone-induced intraocular hypertension in rabbit |
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| CHEN Lin,LIU Su. Effect of low intensity ultrasound on dexamethasone-induced intraocular hypertension in rabbit[J]. Basic Medical Sciences and Clinics, 2007, 27(3): 284-287 |
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| Authors: | CHEN Lin LIU Su |
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| Affiliation: | Department of Ophthalmology, 1. The Children Hospital; 2. The Second Affiliated Hospital, Chongqing University of Medical University, Chongqing 400010, China |
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| Abstract: | Objective To investigate the effect of low-intensity ultrasound on intraocular hypertension and its mechanicsm.Methods The intraocular hypertension rabbits were treated with ultrasound.The intraocular pressure(IOP),trabecular meshwork HE staining,EM microscopy,extracellular matrix through immunohistochemistry were performed.Results After treatment,IOP was descended and trabecula interspace was wider than the control eye.The expression of collagen I,laminin and fibronectin was inhibited.Conclusion Low-intensity ultrasound can decrease IOP.It may be related with the change of histologic structure of trabecular meshwork. |
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| Keywords: | animal model dexamethasone-induced intraocular hypertension ultrasonic therapy |
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