| 青蒿素联合厄洛替尼对肺癌细胞生物学行为的影响 |
| |
| 引用本文： | 赵福成,韩艳茹,贾奎,刘彩莉,刘振洲.青蒿素联合厄洛替尼对肺癌细胞生物学行为的影响[J].天津中医药,2018,35(5):392-396. |
| |
| 作者姓名： | 赵福成 韩艳茹 贾奎 刘彩莉 刘振洲 |
| |
| 作者单位： | 新乡医学院第一附属医院中西医结合科 |
| |
| 摘 要： | 目的]探讨青蒿素联合厄洛替尼对肺癌细胞的活性和凋亡的影响。方法]通过CCK-8实验检测青蒿素和/或厄洛替尼不同浓度处理下A549肺癌细胞的活性;流式细胞术检测青蒿素和厄洛替尼单独或联合作用下A549肺癌细胞凋亡行为变化;小鼠肿瘤内注射实验检测青蒿素和厄洛替尼单独或联合作用下对小鼠成瘤的影响。结果]青蒿素联合厄洛替尼作用A549肺癌细胞时细胞活性下降91%,最佳的用药浓度为10μg/mL青蒿素和10μg/mL厄洛替尼;青蒿素联合厄洛替尼诱导细胞凋亡,凋亡率高达90%,显著高于单独处理组;肿瘤内注射青蒿素和厄洛替尼,使小鼠体内肿瘤体积显著缩小。结论]青蒿素联合厄洛替尼能降低肺癌细胞活性,诱导其凋亡,也能有效地减少体内肿瘤体积。
|
| 关 键 词： | 青蒿素 厄洛替尼 凋亡 细胞活性 |
| 收稿时间： | 2017/12/18 0:00:00 |
Effects of artemisinin combined with erlotinib on lung cancer cells |
| |
| ZHAO Fucheng,HAN Yanru,JIA Kui,LIU Caili and LIU Zhenzhou.Effects of artemisinin combined with erlotinib on lung cancer cells[J].Tianjin Journal of Traditional Chin Medicine,2018,35(5):392-396. |
| |
| Authors: | ZHAO Fucheng HAN Yanru JIA Kui LIU Caili and LIU Zhenzhou |
| |
| Institution: | Department of Integrated TCM & Western Medicine, The First Affiliated Hospital of Xinxiang Medical College, Weihui 453100, China,Department of Integrated TCM & Western Medicine, The First Affiliated Hospital of Xinxiang Medical College, Weihui 453100, China,Department of Integrated TCM & Western Medicine, The First Affiliated Hospital of Xinxiang Medical College, Weihui 453100, China,Department of Integrated TCM & Western Medicine, The First Affiliated Hospital of Xinxiang Medical College, Weihui 453100, China and Department of Integrated TCM & Western Medicine, The First Affiliated Hospital of Xinxiang Medical College, Weihui 453100, China |
| |
| Abstract: | |
| |
| Keywords: | artemisinin erlotinib apoptosis cell activity |
| 本文献已被 CNKI 等数据库收录！ |
| 点击此处可从《天津中医药》浏览原始摘要信息 |
| 点击此处可从《天津中医药》下载免费的PDF全文 |
|
