| 补肾解毒通络方对类风湿关节炎患者血清中血管新生相关因子的影响 |
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| 引用本文： | 何奕坤,杨光辉,郑玥琪,张凯,吴辉辉,潘新,胥晓芳,姚静慧.补肾解毒通络方对类风湿关节炎患者血清中血管新生相关因子的影响[J].天津中医药,2018,35(10):732-735. |
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| 作者姓名： | 何奕坤 杨光辉 郑玥琪 张凯 吴辉辉 潘新 胥晓芳 姚静慧 |
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| 作者单位： | 上海中医药大学附属曙光医院风湿免疫科 |
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| 基金项目： | 国家自然基金项目（青年基金）（81704010）；浦东新区卫生和计划生育委员会卫生科技项目（PW2015D-7）；上海市卫生和计划生育委员会科研课题（20164Y0048）。 |
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| 摘 要： | 目的]观察补肾解毒通络方对活动期类风湿关节炎(RA)患者临床疗效及血清中血管新生相关因子的影响。方法]将78例活动期RA患者随机分为治疗组(n=38)和对照组(n=40)。治疗组予补肾解毒通络方联合甲氨蝶呤治疗,对照组予单药甲氨蝶呤治疗。记录治疗前后患者VAS评分、28处关节疾病活动度评分(DAS28)、中医证候疗效评估、C反应蛋白(CRP)、血沉(ESR)的变化,同时检测血清中VEGF、bFGF、TGF-β1的数值变化,并观察治疗过程中出现的不良反应。结果]治疗6个月后,两组在中医症状评分、VAS、DAS28评分、CRP较治疗前均值均下降(P0.05);治疗组患者血清VEGF、bFGF水平较治疗前降低(P0.05),TGF-β1水平较治疗前升高(P0.05);对照组患者仅血清VEGF、bFGF水平较治疗前降低(P0.05)。两组相比,治疗组中医症状评分、VAS、DAS28评分、CRP均值低于对照组(P0.05);治疗组患者血清VEGF、bFGF水平较对照组明显降低(P0.05),而TGF-β1水平较对照组明显升高(P0.05)。结论]补肾解毒通络方能有效缓解活动期RA临床症状,同时可通过下调RA患者血清中VEGF、bFGF,并上调TGF-β1的表达水平从而抑制新生血管增生,表明该方临床疗效可,且在对RA血管翳的形成可能具有一定的抑制作用。
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| 关 键 词： | 补肾解毒通络方 类风湿关节炎 临床疗效 血管新生相关因子 |
| 收稿时间： | 2018/5/16 0:00:00 |
Effect of Bushen Tongluo Jiedu decoction on the angiogenesis relative factors in the serum of patients with rheumatoid arthritis |
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| HE Yikun,YANG Guanghui,ZHENG Yueqi,WU Huihui,PAN Xin,XU Xiaofang and YAO Jinghui.Effect of Bushen Tongluo Jiedu decoction on the angiogenesis relative factors in the serum of patients with rheumatoid arthritis[J].Tianjin Journal of Traditional Chin Medicine,2018,35(10):732-735. |
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| Authors: | HE Yikun YANG Guanghui ZHENG Yueqi WU Huihui PAN Xin XU Xiaofang and YAO Jinghui |
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| Institution: | Department of Rheumatism, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200021, China,Department of Rheumatism, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200021, China,Department of Rheumatism, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200021, China,Department of Rheumatism, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200021, China,Department of Rheumatism, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200021, China,Department of Rheumatism, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200021, China,Department of Rheumatism, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200021, China and Department of Rheumatism, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200021, China |
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| Abstract: | |
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| Keywords: | Bushen Tongluo Jiedu decoction rheumatoid arthritis clinical efficacy angiogenesis relative factors |
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