大蒜素对感染性休克大鼠血流动力学和血液流变学的影响

目的]研究大蒜素对感染性休克大鼠血流动力学指标和血液流变学指标的影响,探讨大蒜素对感染性休克的保护作用机制。方法]采用尾静脉注射脂多糖(5mg/kg)的方法复制感染性休克大鼠模型,设模型组(生理盐水),大蒜素(3、6、12、24 mg/kg)组,每组20只,另设正常对照组(生理盐水)20只,腹腔注射给药。24 h后测定各组大鼠血流动力学指标、血液流变学指标及血清中血脂监测指标。结果]6、12、24 mg/kg大蒜素能够明显改善感染性休克大鼠血流动力学指标:显著升高动脉收缩压(SAP)、动脉舒张压(DAP)、平均动脉压(MAP)、左心室内压峰值(LVSP)(P0.05或P0.01),显著升高心室内压最大上升速率(lv+dp/dt_(max))并显著缩短心室内压达峰时间(t-dp/dt_(max))(P0.05或P0.01);明显改善血液流变学指标:显著降低全血黏度、血浆黏度、红细胞聚集指数、红细胞变性指数、红细胞刚性指数(P0.05或P0.01);明显改善血脂指标:显著降低血清中总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)含量水平(P0.05或P0.01),其中12、24 mg/kg大蒜素显著升高高密度脂蛋白(HDL-C)含量水平(P0.05)。结论]大蒜素具有改善感染性休克大鼠血流动力学和血液流变学的作用。

Effects of allicin on hemodynamics and hemorheology in septic shock rats

Objective] To study the effect of allicin on hemodynamics and hemorheology in septic shock rats and explore the protective mechanism of allicin on septic shock. Methods] The rat model of septic shock was reproduced by tail vein injection of lipopolysaccharide (5 mg/kg) and were randomly divided into model group, allicin (3, 6, 12, 24 mg/kg) groups (n=20); and set normal control group(n=20). The drugs were administered by intraperitoneal injection. 24 h later, the indexes of hemodynamics, hemorrheology and blood lipid were determined. Results] The index of hemodynamics were significantly improved in allicin (6, 12, 24 mg/kg) groups, including incresing the SAP, DAP, MAP, LVSP (P<0.05 or P<0.01), increasing the lv+dp/dtmax and decreasing t-dp/dtmax; the index of hemorrheolog were significantly improved, including reducing whole blood viscosity, plasma viscosity, erythrocyte aggregation index, erythrocyte degeneration index, erythrocyte rigidity index (P<0.05 or P<0.01); the indexes of blood lipid were significantly improved, including decresing the content of TG, TC, LDL-C and increasing the content of HDL-C (P<0.05 or P<0.01). Conclusion] Allicin has the effect of improving hemodynamics and hemorheology in septic shock rats.