脑血栓片治疗中风病恢复期瘀血阻络证临床疗效观察

[目的]观察脑血栓片治疗缺血性中风病恢复期瘀血阻络证的临床疗效。[方法]采用多中心、随机对照研究方法,将患者随机分为试验组、对照组,各72例。两组均予基础治疗,对照组口服阿司匹林肠溶片100mg,每日1次,试验组在口服阿司匹林肠溶片基础上服用脑血栓片1.2 g,每日3次,两组均服药12周。在治疗6、12周和纳入后24周,采用美国国立卫生研究院卒中(NIHSS)量表、改良Rankin量表、Barthel指数、脑卒中专门化生存质量(SS-QOL)量表、中医症状积分评价其神经功能、日常生活能力、中医症状等方面的疗效。[结果]两组患者治疗后各时点量表评分均较治疗前好转(P0.05);试验组总有效率为90.00%,对照组总有效率为73.44%,差异具有统计学意义(P0.05)。试验组治疗12周时NIHSS量表、Barthel指数、中医症状评分均优于对照组(P0.05)。试验组随访至纳入后24周时NIHSS量表、Barthel指数、SS-QOL量表、中医症状评分均优于对照组(P0.05)。改良Rankin量表比较,两组改善情况相当(P0.05)。[结论]脑血栓片可以有效改善缺血性中风病患者的临床症状,改善神经功能,提高生活质量,其临床疗效确切,值得临床推广应用。

Clinical study of Naoxueshuan tablet against convalescent stroke of blood stagnation obstruction syndrome

[Objective] To observe the clinical efficiency of Naoxueshuan tablets in treating convalescent stroke of blood stagnation obstruction syndrome. [Methods] Patients were divided into experiment group and control group with a multicentre, randomized, and controlled method, 72 cases in each group. Patients in both groups all received basic treatment, and Aspirin Enteric-coated tablets 100 mg once a day was applied to control group, while Naoxueshuan tablets 1.2 g three times a day with Aspirin Enteric-coated tablets 100 mg once a day was applied to experiment group, with a treating period of 12 weeks. NIHSS, modified Rankin, Barthel index, SS-QOL, and traditional Chinese medicine (TCM) symptom score were applied to evaluate the efficiency at 6, 12 and 24 week. [Results] All the scores were improved in both groups after treating (P<0.05). The treatment group efficiency was 90.00%, and control group efficiency was 73.44%, there was significant difference between two groups (P<0.05). NIHSS, Barthel index and TCM symptom scores were better in experiment group than that in control group at week 12 (P<0.05). NIHSS, Barthel index, SS-QOL, and TCM symptom scores were better in experiment group than that in control group at followed up to 24 week(P<0.05). Modified Rankin showed the same improvement in both groups (P>0.05). [Conclusions] Naoxueshuan tablets could significantly improve the symptoms and neural function, raise life quality of convalescent stroke of blood stagnation obstruction syndrome, with a definite curative efficiency, which should be spread and applied widely.