|
|||||
|
|
| 中国人GFPT2基因单核苷酸多态性与北方汉族人群2型糖尿病发生的相关性 | |
| 引用本文： | 班博,陈璐璐,耿厚法,孙琳. 中国人GFPT2基因单核苷酸多态性与北方汉族人群2型糖尿病发生的相关性[J]. 山东医药, 2008, 48(10): 1-2 |
| 作者姓名： | 班博 陈璐璐 耿厚法 孙琳 |
| 作者单位： | 1. 华中科技大学同济医学院附属协和医院,湖北武汉,430030;济宁医学院附属医院 2. 华中科技大学同济医学院附属协和医院,湖北武汉,430030 3. 济宁医学院附属医院 |
| 摘 要： | 目的 研究新诊断2型糖尿病(T2DM)易感基因谷氨酰胺:果糖-6-磷酸酶酰胺转移酶(GFPT)单核苷酸多态性与中国北方汉族人群T2DM的关系.方法 实验分T2DM组和正常对照组,用酚/氯仿法提取其外周血DNA行PCR扩增,分离纯化目的条带后直接测序.结果 GFPT2基因的第14外显子中SNP7位点等位基因为C/T,携带等位基因T的个体T2DM发病率较携带等位基因CC的个体显著升高,两组该等位基因T频率有统计学差异(P<0.01).结论 GFPT2等位基因可能是中国北方汉族人群T2DM主要易感基因位点之一. |
| 关 键 词： | 糖尿病,非胰岛素依赖型 易感基因 单核苷酸多态性 酰基转移酶类 中国人 基因单核苷酸多态性 北方汉族人群 型糖尿病 发生 相关性 Shandong people diabetic mellitus type single nucleotide polymorphism 易感基因位点 统计学差异 频率 发病率 等位基因 外显子 结果 直接测序 分离纯化 |
| 文章编号： | 1002-266X(2008)10-0001-02 |
| 修稿时间： | 2007-11-10 |
Relationship between the single nucleotide polymorphism of GFAT2 and type 2 diabetic mellitus in Han people of Shandong |
|
| BAN Bo,CHEN Lu-lu,GENG Hou-fa,SUN Lin. Relationship between the single nucleotide polymorphism of GFAT2 and type 2 diabetic mellitus in Han people of Shandong[J]. Shandong Medical Journal, 2008, 48(10): 1-2 | |
| Authors: | BAN Bo CHEN Lu-lu GENG Hou-fa SUN Lin |
| Affiliation: | 1 Affiliated United Hospital of Tongji Medical College;Huazhong University of Science and Technology;Wuhan 430030;P.R.China |
| Abstract: | Objective To investigate the relationship between the single nucleotide polymorphism of GFPT2 and type 2 diabetic mellitus(T2DM) in Han people of Shandong.Methods Peripheral blood DNA in subjects from T2DM group and control group was extracted and polymerase chain reaction(PCR)was performed.Results The allele gene of SNP7 in the 14th extron of GFPT2 gene was C/T,the allele T frequency in T2DM group was significantly higher than that in control group(P<0.01).Conclusions The allele gene T of GFPT2 may be the ... |
| Keywords: | diabetes mellitus non-insulin-dependent susceptibility gene single nucleotide polymorphism acyltransferases |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |