多发性骨髓瘤医院感染132例临床研究

目的研究多发性骨髓瘤(MM)患者医院感染的临床特点。方法对住院的132例多发性骨髓瘤患者发生医院感染进行回顾性统计分析。结果132例中38例发生医院感染,感染率28.78%,粒细胞缺乏组的医院感染率91.67%,致死率16.67%,显著高于非粒细胞缺乏组(P<0.01)。感染部位以下呼吸道为主,致病菌以革兰氏阴性菌为主。结论多发性骨髓瘤医院感染率高,粒细胞缺乏是主要危险因素,应采取积极的预防措施,缩短粒缺时间,早期、合理使用敏感抗生素防治感染。

The Clinical research of Nosocomial Infections for Patients with Multiple Myeloma

Objective To study the features of Nosocomial infections for patients with Multiple myeloma (MM). Methods One hundred and thirty-two cases of MM treated in our hospital were analyzed statistically and retrospectively.Results Among 132 patients with MM, 38 patients (28.78%) suffered from nosocomial infections. The incidence of nosocomial infections(91.67%) and the case mortality of nosocomial infections(16.67%) in the granulocytopenia group were significantly higher than those in the non-granulocytopenia group(P<0.01). Most of nosocomial infections took place in the low respiratory tract, and the major infective microorganisms were gram-negative bacilli.Conclusion The incidence of nosocomial infections in patients with Multiple myeloma is high, the granulocytopenia is major inducement. We shoud give more active treatments and prophylaxes to reduce granulocytopenia time, use early and reasonably antibiotics to prevent and treat infections.