工程化的神经干细胞的研究进展

干细胞是目前生物医学领域研究的热点之一.神经干细胞(NSCs)的研究和应用尤为引人注目.神经干细胞是一类广泛存在于中枢神经系统内,能自我复制、自我更新,具有多分化潜能的细胞.所谓工程化的神经干细胞是指利用基因工程等技术,使神经干细胞能高效稳定地表达各种神经营养因子,促进各种中枢神经系统疾病尤其是脊髓损伤的修复.就工程化的神经干细胞的研究现状进行综述,并提出面临的问题和今后的研究方向.

Development of the studies on engineered neural stem cells

Stem cell is one of the hot spot in the research area of biomedical engineering. Special attentions are drawn to the research and application of neural stem cells. Neural stem cells exist widely in central nervous system, which has the capacity of self-renewal and the potential to differentiate into other cells. The so-called engineered neural stem cell is constructed by using the technique of genetic engineering to make it be able to express various neural growth factors with high-performance and stability. The engineered neural stem cells have a great potential in the therapy of diseases of central nervous system, especially the spinal cord injury. This article reviews the research development of engineered neural stem cells, the problems confronted with it, and the trend for research in the future.