Restoration of spatial working memory by genetic rescue of GluR-A-deficient mice |
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| Authors: | Schmitt W B Sprengel R Mack V Draft R W Seeburg P H Deacon R M J Rawlins J N P Bannerman D M |
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| Affiliation: | Department of Experimental Psychology, University of Oxford, South Parks Road, Oxford, OX1 3UD, UK. |
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| Abstract: | Gene-targeted mice lacking the AMPA receptor subunit GluR-A (also called GluR1 encoded by the gene Gria1,) have deficits in hippocampal CA3-CA1 long-term potentiation (LTP) and have profoundly impaired hippocampus-dependent spatial working memory (SWM) tasks, although their spatial reference memory remains normal. Here we show that forebrain-localized expression of GFP-tagged GluR-A subunits in GluR-A-deficient mice rescues SWM, paralleling its rescue of CA3-CA1 LTP. This provides powerful new evidence linking hippocampal GluR-A-dependent synaptic plasticity to rapid, flexible memory processing. |
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