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| 六味地黄丸对动脉粥样硬化小鼠iNOS表达的影响 | |
| 引用本文： | 孙学刚,靖林林,蔡宇,赵益业.六味地黄丸对动脉粥样硬化小鼠iNOS表达的影响[J].中华中医药杂志,2006,21(7):396-398. |
| 作者姓名： | 孙学刚 靖林林 蔡宇 赵益业 |
| 作者单位： | 1. 南方医科大学中医药学院中医证候实验室,广州,510515 2. 暨南大学药学院,广州,510632 3. 广东省中医院心脏中心,广州,510405 |
| 基金项目： | 广东省自然科学基金;广东省中医药管理局科研项目 |
| 摘 要： | 目的:研究六味地黄丸对动脉粥样硬化(AS)小鼠一氧化氮(NO)及诱导型一氧化氮合酶(iNOS)表达的影响。方法:喂饲高脂饲料复制小鼠AS模型;Griess法检测血浆中NO水平;蛋白质免疫印迹法检测iNOS的表达。结果:AS小鼠9周时开始出现NO显著增加,六味地黄丸能显著抑制NO水平,并降低iNOS的表达。结论:六味地黄丸可能通过抑制iNOS的表达降低AS小鼠NO水平,防治AS。 |
| 关 键 词： | 六味地黄丸 诱导型一氧化氮合酶 一氧化氮 动脉粥样硬化 |
| 收稿时间： | 2005-12-29 |
| 修稿时间： | 2005年12月29 |
Effect of Liuwei Dihuang Pill on the Expression of Inducible Nitric Oxide Synthase in Atherosclerosis Mice |
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| Sun Xuegang,Jing Linlin,Cai Yu,Zhao Yiye.Effect of Liuwei Dihuang Pill on the Expression of Inducible Nitric Oxide Synthase in Atherosclerosis Mice[J].China Journal of Traditional Chinese Medicine and Pharmacy,2006,21(7):396-398. | |
| Authors: | Sun Xuegang Jing Linlin Cai Yu Zhao Yiye |
| Institution: | 1 Southern Medical University, Guangdong 510515 ; 2Jinan University, Guangdong 510632; 3Guangdong Hospital of TCM, Guangdong 510405 |
| Abstract: | Objective: To study the effect of Liuwei Dihuang Pill on nitric oxide level and the expression of inducible nitric oxide synthase(iNOS) in BALB/c mice atherosclerosis models.Methods: Three groups of mice were used to reproduce the atherosclerosis models by high fat feeding stuff.Plasma nitric oxide(NO) level was measured by Griess method and the expression of iNOS was detected by western blot method.Results: NO level in atherosclerosis mice increased from the end of the ninth week and increased continuously to the end of the process.Liuwei Dihuang Pill inhibited the increasing of NO level and the expression of iNOS.Conclusion: Liuwei Dihuang Pill may prevent atherosclerosis in mice by inhibiting the expression of iNOS and decline the NO level. |
| Keywords: | Liuwei Dihuang Pill iNOS NO atherosclerosis |
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