Lifelong variations in heart rates in SPF Sprague Dawley rats of both sexes |
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| Authors: | Maurice Stupfel Dominique Costagliola |
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| Affiliation: | (1) U. 123 Research Group, Physiopathological Mechanisms of Environmental Nuisances, INSERM (French National Institute of Health and Medical Research), 44 Chemin de Ronde, F-78110 Le Vesinet, France;(2) Biostatistics Laboratory, U. 21 Statistical Research Unit, Université Paris 7, 2 Place Jussieu, F-75005 Paris, France |
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| Abstract: | In unanesthetized Sprague Dawleys, SPF, of both sexes, housed indl12:12 (110 lux), at a temperature of 18–23°C and a hygrometry of 60–75%, the measurements of heart frequencies during most part of their life point out a continuous decrease with age and an always higher (40–20 c. min–1) heart rate in females than in males. Significant correlations between rate and body weight can account for these heart which corresponds to the growth period, a linear relationship was established between Log heart rate (y;c. min–1) and Log body weight (x; gram); for males: Logy=–0.122 Logx+Log 938 and for females: Logy=–0.166 Logx+Log 1217. After the age of 600 days, which corresponds to senescence, decreases in heart rate as well as in body weight were observed in both sexes.We acknowledge the technical assistance of Serge Hazout, Christian Lemercerre and Micheline Duriez |
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| Keywords: | Heart rate Rat Sex difference Body weight |
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