| 江苏两市MSM抗病毒治疗效果及其影响因素的研究 |
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| 引用本文： | 徐 青,叶 鲁,杨传坤,李建军,王小亮,闫红静,还锡萍,羊海涛. 江苏两市MSM抗病毒治疗效果及其影响因素的研究[J]. 南京医科大学学报(自然科学版), 2014, 0(6): 834-838 |
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| 作者姓名： | 徐 青 叶 鲁 杨传坤 李建军 王小亮 闫红静 还锡萍 羊海涛 |
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| 作者单位： | 东南大学公共卫生学院流行病与卫生统计学系,江苏 南京 210009;南京医科大学公共卫生学院流行病与卫生统计学系,江苏 南京 210029;东南大学公共卫生学院流行病与卫生统计学系,江苏 南京 210009;江苏省疾病预防控制中心,江苏 南京 210009;江苏省疾病预防控制中心,江苏 南京 210009;江苏省疾病预防控制中心,江苏 南京 210009;江苏省疾病预防控制中心,江苏 南京 210009;东南大学公共卫生学院流行病与卫生统计学系,江苏 南京 210009,江苏省疾病预防控制中心,江苏 南京 210009 |
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| 基金项目： | 江苏省医学重点人才项目(RC2011087?RC2011086) |
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| 摘 要： | 目的:分析江苏男男性行为(men who have sex with men,MSM)人群的艾滋病抗病毒治疗效果及其影响因素,首次建立江苏省MSM抗病毒治疗评价方法?方法:通过整群抽样的方式选取江苏两市接受免费高效抗逆转病毒治疗(highly active antiretroviral therapy,HAART)的MSM作为研究对象,进行生活史和用药情况的问卷调查;从江苏省艾滋病治疗信息库中获知其CD4值,采用Epidata 3.0和SAS 9.0分别进行资料录入与统计分析?结果:157例MSM总体CD4值提高,服药依从性低?经单因素及多因素分析,确诊后安全套使用水平低?吸烟量大?确诊至治疗时间间隔长是影响治疗效果的危险因素;首次CD4值较高及服药天数较长是保护因素?结论:江苏目前男男性行为人群抗病毒治疗效果显著,建议对符合治疗条件的MSM进行早期治疗,并提高患者服药依从性?
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| 关 键 词： | 男男性行为者 高效抗逆转录病毒治疗 CD4+T淋巴细胞计数 |
| 收稿时间： | 2013-12-02 |
Efficacy of HAART and its determinants in men who have sex with men in two cities of Jiangsu |
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| Xu Qing,Ye Lu,Yang Chuankun,Li Jianjun,Wang Xiaoliang,Yan Hongjing,Huan Xiping and Yang Haitao. Efficacy of HAART and its determinants in men who have sex with men in two cities of Jiangsu[J]. Acta Universitatis Medicinalis Nanjing, 2014, 0(6): 834-838 |
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| Authors: | Xu Qing Ye Lu Yang Chuankun Li Jianjun Wang Xiaoliang Yan Hongjing Huan Xiping Yang Haitao |
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| Affiliation: | Department of Epidemiology and Health Statistics,College of Public Health,Southeast University,Nanjing 210009;Department of Epidemiology and Health Statistics,College of Public Health,NMJU,Nanjing 210029;Department of Epidemiology and Health Statistics,College of Public Health,Southeast University,Nanjing 210009;Jiangsu Provincial Center for Disease Prevention and Control,Nanjing 210009,China;Jiangsu Provincial Center for Disease Prevention and Control,Nanjing 210009,China;Jiangsu Provincial Center for Disease Prevention and Control,Nanjing 210009,China;Jiangsu Provincial Center for Disease Prevention and Control,Nanjing 210009,China;Department of Epidemiology and Health Statistics,College of Public Health,Southeast University,Nanjing 210009,Jiangsu Provincial Center for Disease Prevention and Control,Nanjing 210009,China |
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| Abstract: | Objective:To analyze the effectiveness and associated factors of highly active antiretroviral therapy (HAART) on men who have sex with men (MSM) in Jiangsu province,and to establish an evaluation system of HAART for MSM in Jiangsu province for the first time. Methods:MSM who received HAART in two cities in Jiangsu province participated in a cluster random sampling. Questionnaires were used to collect information of life history and drug use. CD4 count was acquired from AIDS therapeutic database of Jiangsu province. Epidata 3.0 and SAS 9.0 were used for data entry and statistical analysis,respectively. Results:According to AIDS therapeutic database,the total CD4 count of 157 MSM was increased,while their drug compliances were quite low. Univariable and multivariable statistical analyses showed that low condom usage,heavy smoking,and long-time interval between definite diagnosis and therapy reduced the effect of HAART,while higher CD4 count at the time of starting therapy and longer drug use were protective factors of HAART. Conclusion:Currently,HAART showed significant effect among MSM in Jiangsu province. We recommended performing early treatment and improving drug compliance of HAART among MSM who meet the therapy conditions. |
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| Keywords: | men who have sex with men(MSM) highly active antiretroviral therapy (HAART) CD4+T lymphocyte count |
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