Coronary Vasomotion One Year after Drug-Eluting Stent Implantation: Comparison of Everolimus-Eluting and Paclitaxel-Eluting Coronary Stents |
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Authors: | Michalis Hamilos Flavio Ribichini Miodrag C. Ostojic Valeria Ferrero Dejan Orlic Corrado Vassanelli Nevena Karanovic Giovanna Sarno Thomas Cuisset Panos E. Vardas William Wijns |
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Affiliation: | 1. Cardiology Department, University Hospital of Heraklion, Heraklion, Greece 2. Department of Biomedical Sciences and Surgery, University of Verona, Verona, Italy 3. Department of Cardiology, University Institute for Cardiovascular Diseases, Clinical Center of Serbia, Belgrade, Serbia 4. Cardiovascular Center Aalst, OLV Hospital, Moorselbaan, 164, 9300, Aalst, Belgium
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Abstract: | First-generation drug-eluting stents (DES) have been associated with impaired localized coronary vasomotion and delayed endothelialization. We aimed to compare coronary vasomotion after implantation of a newer-generation everolimus-eluting stent (EES), with a first-generation paclitaxel-eluting stent (PES). Coronary vasomotion was studied in 19 patients with EES and 13 with PES. Vasomotor response was measured proximally and distally to the stent and in a remote vessel (reference segment). Quantitative coronary angiography was performed offline. Endothelium independent vasomotion did not differ significantly between the two groups. EES showed significant vasodilatation while PES showed vasoconstriction at both proximal (+4.5?±?3.6 vs ?4.2?±?6.9, p?0.001) and distal (+4.6?±?7.9 vs ?4.8?±?9.3, p?=?0.003) segments. The reference segment did not show any significant difference in vasodilatation between the two groups (+9.8?±?6.4 vs +7.2?±?5.2, p?=?0.17). Endothelium-dependent vasomotion at adjacent stent segments is relatively preserved after EES implantation while vasoconstriction was observed after PES implantation. |
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