| 小剂量拉莫三嗪与丙戊酸合用治疗成人癫痫临床观察 |
| |
| 引用本文： | 张美云,王凤楼.小剂量拉莫三嗪与丙戊酸合用治疗成人癫痫临床观察[J].国际神经病学神经外科学杂志,2008,35(4). |
| |
| 作者姓名： | 张美云 王凤楼 |
| |
| 作者单位： | 1. 天津市人民医院神经内科,天津市,300121
2. 天津医科大学总医院神经内科,天津市,300052 |
| |
| 摘 要： | 目的 研究小剂量拉莫三嗪与丙戊酸合用治疗成年人各种类型癫痫的有效件和安全性.方法 对100例成年癫痫患者采用逐步增量的方法给予拉莫三嗪至每目100 mg,加约期4周,并继续服用原剂量的丙戊酸治疗,连续观察6月,记录患者发作的情况及不良反应.结果 小剂量拉其三嗪与丙戊酸合用总有效率为77.2%,完全控制50.O%,各种类型发作之间疗效比较差异无显著性(χ2=1.37,P>0.05);各型癫痫在人组4～6个月后较入组前3个月发作频率均减少,差异有显著性(P<0.05).不良反应发生率23.7%,与入组前后小良反应发牛率相比无显著变化(χ2=0.21,P>0.05).结论 小剂量托莫二三嗪与丙戊酸合用治疗成年人各种类犁癫痫均取得良好疗效,不良反应无增加.
|
| 关 键 词： | 拉莫三嗪 丙戊酸 癫痫 |
Coadministration of low dose of Lamotrigine and valproate in treatment of epilepsy in adults |
| |
| ZHANG Mei-yun,WANG Feng-lou.Coadministration of low dose of Lamotrigine and valproate in treatment of epilepsy in adults[J].Journal of International Neurology and Neurosurgery,2008,35(4). |
| |
| Authors: | ZHANG Mei-yun WANG Feng-lou |
| |
| Institution: | ZHANG Mei-yun,WANG Feng-lou.Department of Neurology,People Hospital of Tianjin,Tianjin 300121,China |
| |
| Abstract: | Objective To study the efficacy and safety of coadministration of low dose of Lamotrigine and valproate in treatment of epilepsy in adults.Methods An open-label self-control study was performed.One hundred patients with epilepsy were enrolled.After they received at least 3 months valproate treatment,Lamotrigine was added at an increasing dose from 12.5 mg/d to the target dose of 100 mg/d.The efficacy and safety were observed for 6 months.Results The total effective rate of coadministration of Lamotrigine an... |
| |
| Keywords: | Lamotrigine Valproate Epilepsy |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
