| 儿童急性白血病G-CSF自身抗体及其对G-CSF血清浓度的影响 |
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| 引用本文： | 孙金英,刘乐宇,刘明泽,刘桂兰,殷惠君. 儿童急性白血病G-CSF自身抗体及其对G-CSF血清浓度的影响[J]. 北京医学, 2000, 22(3): 135-137 |
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| 作者姓名： | 孙金英 刘乐宇 刘明泽 刘桂兰 殷惠君 |
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| 作者单位： | 北京医科大学人民医院儿科,100044 |
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| 摘 要： | 目的 研究急性白血病患儿应用ｒｈＧ－ＣＳＦ后自身抗体的产生及对Ｇ－ＣＳＦ血清浓度的影响。方法 应用ＥＬＩＳＡ技术检测４６例急性白血病患儿和１０４例正常儿童。结果１１例应用ｒｈＧ－ＣＳＦ的急性白血症患儿检测到自身抗体。结论 Ｇ－ＣＳＦ自身抗体的产生与ｒｈＧ－ＣＳＦ剂量和疗程无关，且不显著地降低Ｇ－ＣＳＦ血清浓度。ｒｈＧ－ＣＳＦ临床应用具有安全性。
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| 关 键 词： | 自身抗体 白血病 |
Occurrence of therapy-induced autoantibodies to G-CSF and their influence on serum G-CSF concentration in children with acute leukemia |
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| Sun Jinying,Liu Leyu,Liu Mingze,et al. Occurrence of therapy-induced autoantibodies to G-CSF and their influence on serum G-CSF concentration in children with acute leukemia[J]. Beijing Medical Journal, 2000, 22(3): 135-137 |
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| Authors: | Sun Jinying Liu Leyu Liu Mingze et al |
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| Abstract: | Objective To investigate the occurrence of autoantibodies after using rhG CSF in children with acute leukemia and their influence on serum G CSF concentration.Methods Blood samples collected from 46 patients with acute leukemia and 104 normal children were measured with ELISA technique.Results Autoantibodies were detected in 11 children with acute leukemia.Conclusions The occurrence of G CSF autoantibodies have no significant relationship to rhG CSF doses and courses,and have no influence on serum G CSF concentration.Clinical application of rhG CSF is safety. |
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| Keywords: | G-CSF |
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