宫颈病变与人乳头瘤病毒感染关系探讨

目的探讨宫颈病变与人乳头瘤病毒感染之间的关系。方法回顾分析377例经宫颈涂片细胞学检查证实的宫颈病变患者，其中重度炎症109例、不典型鳞状上皮细胞65例、轻度宫颈上皮内瘤样病变125例、中度宫颈上皮内瘤样病变35例、高度宫颈上皮内瘤样病变30例和宫颈癌13例，分别对以上六组患者采用第二代杂交捕获实验行13种高危人乳头瘤病毒检查、阴道镜下活检及宫颈锥切，将标本送病理检查。结果重度炎症、不典型鳞状上皮细胞、轻度宫颈上皮内瘤样病变、中度宫颈上皮内瘤样病变、重度宫颈上皮内瘤样病变和宫颈癌患者感染高危人乳头瘤病毒者分别为17例、21例、77例、33例、30例和13例，感染率依次为15％、35％、61％、94％、100％和100％。结论宫颈病变程度越严重，13种高危人乳头瘤病毒感染率越高。

Relationship between Cervical Lesions and Human Papillomavirus Infection

Objective To explore the relationship between cervical lesions and the infection of high- risk human papillomavirus. Methods 377 cases with cervical lesions proved by patholog were reviewed retrospectively. Of these patients, there were severe infection 109 cases, atypical squamous cell 65 cases, slight degree cervical intraepithelial neoplasia 125 cases, medium degree cervical intraepithelial neoplasia 35 cases, serious degree cervical intraepithelial neoplasia 30 cases and cervical cancer 13 cases. The hybrid capture II test for possible infection of the 13 types of high - risk human papillomavirus, cervical biopsy under colposcope and cervical conization were performed to those patients above. Results Of the severe infection , atypical squamous cell, slight degree cervical intraepithelial neoplasia, medium degree cervical intraepithelial neoplasia , serious degree cervical intraepithelial neoplasia and cervical cancer cases, there were 17,21,77,33,30 and 13 cases infected with 13 types of high- risk human papillomavirus respectively. The rates of infection were 15% ,35% ,61% , 94% ,100% and 100% in turn. Conclusion The more severe the cervical lesions are, the higher the infection rate of the 13 types of high -risk human papillomavirus.