| 黄芩素脂质体的制备及体外释放的研究 |
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| 引用本文： | 姚亚红,张立伟.黄芩素脂质体的制备及体外释放的研究[J].中医药学报,2006,34(3):31-33. |
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| 作者姓名： | 姚亚红 张立伟 |
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| 作者单位： | 山西大学分子科学研究所,山西,太原,030006 |
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| 摘 要： | 目的:研究黄芩素脂质体的制备方法。方法:采用逆相蒸发法、薄膜-超声法制备黄芩素脂质体,利用紫外光谱测定包封率以及浆板法测定体外释放曲线。结果:逆相蒸发制备的脂质体平均粒径179nm,包封率和载药量分别为92.57%和23.24%;薄膜超声法平均粒径257nm,包封率和载药量分别为60.02%和7.70%,在PH7.4磷酸盐缓冲液中体外释药符合Higuchi方程。结论:逆相蒸发法操作简单,重现性好,制备的脂质体粒径小、包封率高,药物具有一定的缓释性。
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| 关 键 词： | 黄芩素 脂质体 包封率 制备 |
| 文章编号： | 1002-2392（2006）03-0031-03 |
| 收稿时间： | 2005-09-02 |
| 修稿时间： | 2005-09-02 |
Studies on preparation technique and in vitro release of baicalein Iiposomes |
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| YAO Ya-hong,ZHANG Li-wei.Studies on preparation technique and in vitro release of baicalein Iiposomes[J].Acta Chinese Medicine and Pharmacology,2006,34(3):31-33. |
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| Authors: | YAO Ya-hong ZHANG Li-wei |
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| Abstract: | Objective:To study the optimal operation conditions preparing baicalein liposomes. Method: Baicalein liposomes were prepared by two different method:reverse-phase evaporation and thin-film ultrasonic dispersion.The liposomes and free baicalein were separated by centrifu-gation, the drug loading (DL) and entrapment efficiency (EE) of baicalein liposomes were determined by UV-method. Results: The mean diameter EE and DL of baicalein liposomes by reverse-phase evaporation were 179nm,92.57% and 23.24% ;275nm,60.02% and 7.70% by thin-film ultrasonic dispersion. In a buffer of pH7. 4which was prepared from NaH2PO4-Na2HPO4, system,the drug release in vitro was found to be matched up with Higuchi equation. Conclusion: Reverse-phase evaporation method of baicalein liposomes preparation is easy and efficient. |
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| Keywords: | Baicalein liposomes Entrapment efficiency Preparation |
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