稳定期中重度慢性阻塞性肺疾病患者运动能力影响因素分析

目的探讨中重度慢性阻塞性肺疾病(COPD)患者运动能力的影响因素。方法30例稳定期中重度COPD患者，运动前均进行常规肺功能检查、血气分析和生命质量问卷词查。运动过程中监测胸腹呼吸运动之和与潮气容积之比(代D/VT)。结果相关分析显示，反映最大运动能力的各指标与一氧化碳弥散量占预计值比、残/总百分比、用力肺活量、第一秒用力呼气容积、最大呼气流速和静息时动脉氧分压均有较强的相关性；与生命质量评分VEmax和VTmax均显著相关。结论中重度COPD患者运动时通气限制是影响运动能力的重要因素，最大运动能力下降与基础肺功能损害特别是弥散障碍有关；生存质量下降可显著影响患者的运 动能力。

Determinants of exercise capacity in patients with chronic obstructive pulmonary disease(COPD)

Objective To evaluate the factors affecting exercise ability of patients with moderate to severe chronic obstructive pulmonary disease(COPD) . Methods Rutine examination of lung function, analysis of blood gas and health - related quality of life(HRQoL) wereperformed before exercise in 30 patients. The ratio of thoracoabdominal motion to votile volume(TCD/VT) was monitored during exer-cise. Results Revelant analysis indicated indeies responed to maximal exercise capacity were closely related to the ratio of the amount of co2diffused to expected value, resident volume/total volume, FEV1, FVC, PEFR and resting PaO2, VE, VT. Conclusion Restriction of ventila-tion is a main factor affecting exercise capacity of patients with moderate to severe COPD. Basic pulmonary impairment and the decrease ofHRQoL also affect patient's exercise capacity.