曲美他嗪治疗不稳定型心绞痛的疗效观察及其对C-反应蛋白的影响

目的评价曲美他嗪治疗不稳定型心绞痛的疗效及其对C-反应蛋白(CRP)的影响。方法我院43例符合标准的不稳定型心绞痛患者随机分为对照组(22例)和治疗组(21例)。对照组患者给予基础治疗(硝酸酯类,β-受体阻滞剂,抗凝剂及阿司匹林等),治疗组在此基础上加用曲美他嗪,疗程均为4周。治疗前、后进行心电图检查,记录心绞痛发作次数及每次心绞痛发作的时间,同时检测治疗前后血清C-反应蛋白含量。结果两组患者临床疗效差异有统计学意义(P0.05)。两组患者治疗后心绞痛发作次数、持续时间、C-反应蛋白含量差异均有统计学意义(P0.05)。结论曲美他嗪可明显改善不稳定型心绞痛患者临床疗效,显著降低不稳定型心绞痛患者血清CRP水平。

To Observe the Curative Effect of Trimetazidine on the Patients with Unstable Angina Pectoris and the Influence of Trimetazidine on C-reactive Protein

Objective To evaluate the curative effect of trimetazidine on the patients with unstable angina pectoris and the influence of trimetazidine on c-reactive protein(CRP).Methods 43 patients with unstable angina pectoris were divided into two groups by randomly: the controlled group(n=22)and the test group(n=21).In the controlled group,patients accepted the treatment with nitrate,β—blocker and aspirin,in the test group,trimetazidine were given in addition to conventional therapy.The treatment durations in both groups were 4 weeks.Evaluate the clinical effect and change of the electrocardiogram and the frequency and the lasting time of angina;at the same time,to detect the change of c-reactive protein level in serum of the patients with unstable angina pectoris.Results Two groups of patients with clinical efficacy difference was statistically significant(P<0.05).Two groups of patients after treatment,the attack of angina frequency,duration difference was also statistically significant(P<0.05).Conclusion Trimetazidine can obviously improve the clinical curative effect on the patients with unstable angina pectoris by notable depressing the level of CRP.