| SIRT1在呼吸道病原微生物感染中的作用研究进展 |
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| 引用本文： | 李海燕,林立,李昌崇. SIRT1在呼吸道病原微生物感染中的作用研究进展[J]. 国际呼吸杂志, 2017, 37(10). DOI: 10.3760/cma.j.issn.1673-436X.2017.10.010 |
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| 作者姓名： | 李海燕 林立 李昌崇 |
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| 作者单位： | 325027,温州医科大学附属第二医院 育英儿童医院儿童呼吸科 |
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| 基金项目： | 2017年度浙江省自然科学青年基金，2014年浙江省教育厅一般科研项目，温州市2014年公益性科技计划项目(Y20140668)NaturalScience Foundation of Zhejiang province，General Scientific Research Project of Zhejiang Province，The Public Welfare of Science and Technology Plan Projects of Wenzhou |
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| 摘 要： | SIRT1称为沉默信息调节因子1,是一种烟酰胺腺嘌呤二核苷酸依赖的组蛋白去乙酰化酶,在能量代谢、细胞生长周期调节、DNA损伤修复、抗氧化应激、延缓衰老、抗炎等方面发挥作用.本文结合国内外最新研究报道对SIRT1的抗炎作用信号转导通路进行总结;对细胞水平或动物试验已证实的机体SIRT1在呼吸道病原微生物感染中的作用进行综述.
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| 关 键 词： | 沉默信息调节因子1 病毒 细菌 |
Advancement of effects study on SIRT1 in the infection of respiratory pathogenic microorganisms |
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| Li Haiyan,Lin Li,Li Changchong. Advancement of effects study on SIRT1 in the infection of respiratory pathogenic microorganisms[J]. International Journal of Respiration, 2017, 37(10). DOI: 10.3760/cma.j.issn.1673-436X.2017.10.010 |
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| Authors: | Li Haiyan Lin Li Li Changchong |
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| Abstract: | SIRT1 is named silent information regulator 1.It is an NAD(+)-dependent histone deacetylase involved in various life events such as energy metabolism,life cycles,DNA repair,antioxidant stress,anti-aging and anti-inflammation.This article summarizes the signal transduction pathways of SIRT1 according to recently researches and reviews the function of SIRT1 which were confirmed from cellular level and animal experiments including in the infection of respiratory pathogenic microorganisms. |
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| Keywords: | SIRT1 Virus Bacteria |
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