| COPD相关T淋巴细胞亚群的新功能 |
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| 引用本文： | 尹琦,任涛,沈瑶,唐瑜瑆.COPD相关T淋巴细胞亚群的新功能[J].国际呼吸杂志,2017,37(19). |
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| 作者姓名： | 尹琦 任涛 沈瑶 唐瑜瑆 |
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| 作者单位： | 同济大学附属东方医院呼吸内科, 上海,200120 |
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| 基金项目： | 浦东新区卫生系统重点学科，上海市优秀学术带头人计划(16XD1403100)Key Discipline of Pudong New Area Health System，Shanghai Outstanding Academic Leaders Plan |
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| 摘 要： | 肺部慢性非特异性炎症被认为是COPD发生发展的病理基础,淋巴细胞在调节 COPD气道炎症中发挥重要的作用.研究发现,效应T细胞、抑制性 T细胞与耗竭 T细胞三者在 COPD的炎症调节中发挥着不同的正负调节效应,它们分化上互相关联,功能上互相拮抗,一旦发生免疫失衡,可加重气道结构的破坏、加速COPD的进展和恶化.
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| 关 键 词： | 慢性阻塞性肺疾病 CD4+T细胞 CD8+T细胞 调节性T细胞 耗竭T细胞 |
New function of COPD associated T lymphocytes subsets |
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| Yin Qi,Ren Tao,Shen Yao,Tang Yuxing.New function of COPD associated T lymphocytes subsets[J].International Journal of Respiration,2017,37(19). |
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| Authors: | Yin Qi Ren Tao Shen Yao Tang Yuxing |
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| Abstract: | Chronic non-specific inflammation of lung was considered to be the pathogenesis of chronic obstructive pulmonary disease (COPD) development,lymphocytes play an important role in regulating COPD airway inflammation.Studys found that effector T cells,inhibitory T cells and exhausted T cells play different positive and negative regulatory effect in COPD inflammatory regulation.They are interrelated on differentiation and antagonistic on function.Once the immune imbalance occurs,which can aggravate the damage of airway structure,accelerate the progression and deterioration of COPD. |
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| Keywords: | Chronic obstructive pulmonary disease CD4+T cells CD8+T cells Regulatory T cell Exhausted T cells |
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