| 激活素A在呼吸系统疾病中的作用 |
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| 引用本文： | 李晶晶,朱述阳. 激活素A在呼吸系统疾病中的作用[J]. 国际呼吸杂志, 2017, 37(7). DOI: 10.3760/cma.j.issn.1673-436X.2017.07.010 |
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| 作者姓名： | 李晶晶 朱述阳 |
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| 作者单位： | 1. 221000,徐州医科大学;2. 221000,徐州医科大学附属医院呼吸内科 |
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| 摘 要： | 激活素A (activin A,ACT-A)是转化生长因子β(transforming growth factor-β,TGF-β)超家族中的一种多效性细胞因子,能够调节细胞增殖、分化、损伤修复、凋亡.近年的研究显示:ACT-A与支气管哮喘(简称哮喘)、COPD、肺纤维化等多种肺部疾病的发生和发展密切相关,而通过卵泡抑素阻断ACT-A信号传导对抑制这类疾病有潜在的治疗价值.本文就ACT-A在呼吸系统疾病中的作用及其机制作一综述.
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| 关 键 词： | 激活素A 支气管哮喘 慢性阻塞性肺疾病 肺纤维化 囊性肺纤维化 |
Effect of activin A in respiratary disease |
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| Li Jingjing,Zhu Shuyang. Effect of activin A in respiratary disease[J]. International Journal of Respiration, 2017, 37(7). DOI: 10.3760/cma.j.issn.1673-436X.2017.07.010 |
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| Authors: | Li Jingjing Zhu Shuyang |
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| Abstract: | Activin A (ACT-A) is a pleiotropic cytokinethat belongs to the transforming growth factor beta (TGF-β) superfamily and plays an important role incell proliferation,differentiation,apoptosis and repair.Recent studies show that ACT-A is related to the occurrence and development of bronchial asthma,COPD,pulmonary fibrosis and other pulmonary diseases closely.Follistatinhas the potential therapeutic value through blocking ACT-A signal transduction to suppress this kind of disease.This article reviews the role and mechanism of ACT-A in respiratory diseases. |
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| Keywords: | Activin A Bronchial asthma Chronic obstructive pulmonary disease Pulmonary fibrosis Cystic fibrosis |
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