炎性树突状细胞的功能特性及在支气管哮喘发病机制中的作用

树突状细胞是功能最强的专职抗原递呈细胞,作为机体免疫应答的启动者在免疫应答中占有重要地位.研究显示在感染或炎症状态下由炎性单核细胞分化而来的一种树突状细胞亚型——炎性树突状细胞,参与调节免疫应答.近来,炎性树突状细胞在支气管哮喘发生机制中的作用备受关注,现就炎性树突状细胞在不同类型免疫应答的作用及其与支气管哮喘的关系作一综述.

Functional properties of inflammatory dendritic cells and its role in the pathogenesis of bronchial asthma

Dendritic cells (DCs) are the most proficient professional antigen-presenting cells,which play crucial roles in priming the immune responses.However,some research suggests that inflammatory DCs,an additional subset of DCs,which differentiate from inflammatory monocytes during infection or inflammatory conditions,involves in the regulation of immune responses.In recent years,the role of inflammatory DCs in the pathogenesis of bronchial asthma has aroused full attention.Here is a review about the role of inflammatory DCs in different types of immune responses and the relationship between inflammatory DCs and bronchial asthma.