巨噬细胞在支气管哮喘中的作用及研究进展

受微环境变化的影响,巨噬细胞分为经典激活的巨噬细胞(M1)和非经典激活的巨噬细胞(M2).M1型巨噬细胞可释放如肿瘤坏死因子α(TNF-α)和IL-1β等促炎因子加重炎症反应,也可因极化的增多发挥抗炎作用.M2型巨噬细胞分为M2a、M2b和M2c 3种亚型,M2a及M2b型巨噬细胞主要产生炎性细胞因子如ID4和IL-13,M2c型巨噬细胞主要产生抗炎细胞因子如IL-10并有很强的吞噬功能.细胞因子、趋化因子和免疫调节细胞影响着M1型和M2型巨噬细胞的平衡.巨噬细胞不同的极化在支气管哮喘发生与发展中起到重要的作用.

The role of macrophages in bronchial asthma and research progress

Affected by microenvironment change macrophages can be divided into classical activated macrophages (M1) and nonclassical activated macrophages (M2).M1 macrophages can release such as TNF-α and IL-13 proinflammatory factor to aggravate inflammation,meanwhile the increased polarization can play a role of anti-inflammatory.M2 macrophages are divided into M2a,M2b and M2c.M2a and M2b macrophages mainly produce inflammatory cytokines such as IL-4 and IL-13,M2c type has a strong phagocytosis and it mainly produce anti-inflammatory cytokines such as IL-10.Cytokines and chemokines and immune regulating cell affects the balance of the M1 and M2 macrophages.The different polarization of macrophages play an important role in bronchial asthma.Now the related research of macrophages and bronchial asthma were reviewed as follows.