红细胞分布宽度和血清胱抑素C对COPD继发肺动脉高压的预判价值比较

目的 比较红细胞分布宽度 (RDW)和血清胱抑素 C (Cys-C)对 COPD 继发肺动脉高压的预判价值.方法 纳入2014年5月至2016年4月就诊的114例单纯COPD患者和66例COPD合并肺动脉高压患者,测量其血清 RDW 和 Cys-C 水平,比较并评价它们对肺动脉高压的预测价值.结果 合并组患者的血清 RDW和Cys-C水平均显著高于单纯 COPD患者 (P<0.05);RDW和 Cys-C预测COPD合并肺动脉高压的准确性均是74%,两者的敏感性、特异性和准确性等指标差异均无统计学意义 (P>0.05);血清 RDW水平与肺动脉压力呈正相关 (r=0.416,P =0.002),Cys-C水平与肺动脉高压的严重程度无显著相关性 (r=0.225,P =0.307).结论 虽然 RDW和 Cys-C 对 COPD合并肺动脉高压的预测准确性无明显差别,但 RDW与肺动脉压力显著相关,因此在临床中更具应用价值.

Comparison of red blood cell distribution width and serum cystatin C in predicting pulmonary hypertension secondary to chronic obstructive pulmonary disease

Objective To compare the red blood cell distribution width(RDW)and serum cystatin C(Cys-C)in predicting pulmonary hypertension secondary to chronic obstructive pulmonary disease (COPD).Methods One hundred and fourteen patients with COPD and 6 6 COPD patients with pulmonary hypertension from May 2014 to April 2016 were enrolled in this study,their serum RDW and Cys-C levels were measured and compared to evaluate their predictive value for pulmonary hypertension. Results The RDW and Cys-C levels in the pulmonary hypertension group were significantly higher than those in the COPD patients(P <0.05).The accuracy of RDW and Cys-C in predicting COPD with pulmonary hypertension was 74%,and their sensitivity,specificity,and accuracy were no difference(P>0.05).RDW was positively correlated to the pulmonary artery pressure(r=0.416,P =0.002),while Cys-C was not correlated to the severity of pulmonary hypertension(r=0.225,P=0.307).Conclusions Although RDW and Cys-C have no significant difference in predictive of COPD with pulmonary hypertension,RDW is significantly associated with pulmonary artery pressure,so it is more valuable in clinical practice.