多囊卵巢综合征的辅助生殖技术治疗

多囊卵巢综合征(polycystic ovary syndrome,PCOS)是育龄期妇女常见的内分泌疾病,不孕是其主要的临床特点之一。在经过控制体质量、调整生活方式、氯米芬和芳香化酶抑制剂促排卵治疗、低剂量促性腺激素诱导排卵后,辅助生殖技术(assisted reproductive technology,ART)可能是治疗不孕的有效方法。但由于PCOS患者病因复杂,常伴有肥胖、代谢异常等,在实施ART时需根据患者的临床表现、辅助检查、患者对药物的反应性等给予个体化的治疗方案,进行改善代谢状态的预处理,同时要采取相应的措施预防卵巢过度刺激综合征(ovarian hyperstimulation syndrome,OHSS)等并发症的出现。综合国内外文献,就PCOS的助孕现状、ART在预处理、个性化方案和预防并发症三方面的新进展分别进行阐述。

Assisted Reproductive Technology of Polycystic Ovary Syndrome:A Review

Infertility is one of clinical features of polycystic ovary syndrome (PCOS),a common endocrine disease in women of childbearing age.After weight control,lifestyle adjustment,clomiphene citrate and aromatase inhibitors induced ovulation,and/or low-dose gonadotropin induced ovulation,assisted reproductive technology (ART) may be an effective treatment.However,PCOS patients have complex etiologies,and often accompanied by obesity and metabolic abnormalities,the individualized treatment should be taken according to their clinical manifestations,examination and responses to drugs such as correction of endocrine disorders.It is important to prevent ovarian hyperstimulation syndrome (OHSS),and other complications,during ovulation induction.This paper reviews the application of ART in the pretreatment and individualized programs of PCOS,as well as the prevention of complications.