| 多黏菌素的药理作用和治疗多重耐药鲍曼不动杆菌的研究进展 |
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| 引用本文： | 刘聪蕊,柯蕊,刘原.多黏菌素的药理作用和治疗多重耐药鲍曼不动杆菌的研究进展[J].国际呼吸杂志,2017,37(20). |
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| 作者姓名： | 刘聪蕊 柯蕊 刘原 |
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| 作者单位： | 710004,西安交通大学第二附属医院呼吸内科 |
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| 摘 要： | 随着全球多重耐药鲍曼不动杆菌的感染率、致死率日益增多,且对碳青霉烯类耐药现象十分常见,多黏菌素作为治疗多重耐药鲍曼不动杆菌的最后防线被引入临床.本文旨在对多黏菌素的化学结构、作用机制、耐药机制、单用及联合应用和毒性作用进行综述,以期对临床科学合理用药和进一步研究提供参考.
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| 关 键 词： | 多黏菌素 鲍曼不动杆菌 研究进展 |
Pharmacological effects and research advances of polymyxin in the treatment of multi-drug resistent Acinetobacter baumannii |
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| Liu Congrui,Ke Rui,Liu Yuan.Pharmacological effects and research advances of polymyxin in the treatment of multi-drug resistent Acinetobacter baumannii[J].International Journal of Respiration,2017,37(20). |
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| Authors: | Liu Congrui Ke Rui Liu Yuan |
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| Abstract: | With the increasing infection rate and fatality rate of global multi-drug resistent Acinetobacter baumannii,and carbapenem resistance is very common,polymyxin as the treatment of multi-drug resistant Acinetobacter baumannii last line of defense was introduced into clinical.The aim of this study is to provide a reference for the chemical structure,mechanism,drug resistence mechanism, monotherapy and combination therapy and nephrotoxicity of polymyxin. |
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| Keywords: | Polymyxin Acinetobacter baumannii Research progress |
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