滤泡辅助T细胞相关分子与支气管哮喘

滤泡辅助性T细胞(T follicular helper cells,Tfh)是近来发现的CD4+T细胞亚群,它能够迁移至次级淋巴中心的B细胞滤泡,促进生发中心反应,包括调节生发中心的形成、发展和成熟以及辅助B细胞产生具有免疫功能的球蛋白及影响类别转换.Tfh能连续产生趋化因子受体5,在其配体CXCL13的作用下,外周的Tfh被募集至生发中心的B淋巴滤泡,参加生发中心的形成.诱导性共刺激分子和CO40L可以与B细胞表面的配体结合可以调节Tfh分泌IL-21参与B细胞的免疫应答,参与体液免疫.支气管哮喘(简称哮喘)发病机制复杂,T淋巴细胞在哮喘的气道炎症反应中起重要作用.本文回顾了Tfh细胞相关分子在哮喘气道炎症中的作用.

T follicular helper cells-associated molecules and bronchial asthma

T follicular helper cells (Tfh),a recently discovered subset of CD4+ T cells,are able to migrate to B-cell follicles in the center of the secondary lymph,and promote germinal center response,including regulating the formation,development and maturation of germinal center,as well as assist B cells to produce immunoglobulins and influence there switching.Tfh can continuously produce chemokine receptor 5,which in combination with CXCL13,promptete peripheral Tfh cells to raise to the germinal center of the B lymphoid follicles and participate in the formation of germinal centers.Inducible T cell costimulator and CO40L can bind to the B cell surface ligand to regulate secretion of IL-21 on Tfh,which involved in B cell immune response,involved in humoral immunity.The pathogenesis of bronchial asthma (asthma) is very complicated,and T lymphocytes play a central role in the airway inflammation of asthma.This article reviews the role of Tfh cells-associated molecules in airway inflammation in asthma.