| 核转录因子E2相关因子2启动子CpG岛甲基化对其蛋白表达及COPD的影响 |
| |
| 引用本文： | 付聪丽,卞涛.核转录因子E2相关因子2启动子CpG岛甲基化对其蛋白表达及COPD的影响[J].国际呼吸杂志,2017,37(19). |
| |
| 作者姓名： | 付聪丽 卞涛 |
| |
| 作者单位： | 1. 214000,南京医科大学无锡临床医学院;2. 214000,南京医科大学附属无锡市人民医院呼吸内科 |
| |
| 摘 要： | 核转录因子E2相关因子2 (nuclear factor erythroid-2-related factor 2,Nrf2)在人体氧化与抗氧化平衡过程中起了重要的作用.氧化与抗氧化失衡是COPD的重要发病机制之一.近来有研究发现 Nrf2启动子CpG岛甲基化能够影响 Nrf2蛋白的表达,从而影响抗氧化防御过程.明确 Nrf2启动子CpG岛甲基化与 Nrf2蛋白表达及COPD的关系,对今后临床上治疗 COPD寻找新途径具有重要意义.
|
| 关 键 词： | 核转录因子E2相关因子2 甲基化 抗氧化反应 慢性阻塞性肺疾病 |
Relation of promoter CpG island methylation of Nrf2 gene with Nrf2 expression and COPD |
| |
| Fu Congli,Bian Tao.Relation of promoter CpG island methylation of Nrf2 gene with Nrf2 expression and COPD[J].International Journal of Respiration,2017,37(19). |
| |
| Authors: | Fu Congli Bian Tao |
| |
| Abstract: | Nuclear factor erythroid-2-related factor 2(Nrf2)plays a vital role in the antioxidant system.Oxidant/antioxidant imbalance is one of the important pathogenesis of COPD.Recent studies unveiled that the promoter CpG island methylation of Nrf2 gene could impact Nrf2 expression and antioxidant system.Determing the relations among promoter CpG island methylation of Nrf2 gene,Nrf2 expression and COPD makes significance to new therapy of COPD in the future. |
| |
| Keywords: | Nuclear factor erythroid-2-related factor 2 Methylation Antioxidant reaction Chronic obstructive pulmonary disease |
| 本文献已被 万方数据 等数据库收录！ |
