子宫内膜癌中VEGF-C及其受体mRNA的表达及临床意义

目的 研究子宫内膜癌组织中血管内皮生长因子C及其受体mRNA的表达情况,分析其在肿瘤转移中的作用.方法 采用RT-PCR法分析48例新鲜子宫内膜癌组织标本中VEGF-C/KDR/Flt-4mRNA的表达情况,并分析其与各临床病理参数之间的关系.结果 48例子宫内膜癌组织中的VEGF-C及其受体mRNA表达率明显高于正常子宫内膜组织,肿瘤组织中VEGF-CmRNA表达与Flt-4mRNA的表达呈显著正相关.结论 VEGF-C可能在子宫内膜癌转移尤其是淋巴转移中起重要作用,是一个反映病人淋巴转移和预后的良好指标.

Clinicopathological significance of vascular endothelial growth factor C and its receptors in endometrial adenocarcinoma

Objective To investigate the expression of vascular endothelial growth factor-C(VEGF-C) and its receptor in endometrial adenocarcinoma tissue in pursuit of their role in tumor metastasis and other clinical significance.Methods 48 fresh endometrial adenocarcinoma tissue were examined by RT-PCR to detect the VEGF-C/KDR /Flt-4mRNA expression.Results There was a significant difference of VEGF-C/KDR /Flt-4mRNA expression between the tumor and the normal controls.And there was no significant relationship between VEGF-C mRNA,KDR mRNA or flt-4mRNA expression with the pathological types and clinical stage of invasive carcinoma of cervix.But the expression was significant association with the grade of tumor pathology,lymph node metastasis,tumor size and the invasion of deep muscular layer(P<0.05).Conclusion The results suggest that the VEGF-C may play an important role in the lymph node metastasis and it could be a useful biological marker to foresee the lymph node metastasis and prognosis for cervical cancer.