Human papilloma virus infection (condyloma) of the cervix and cervical intraepithelial neoplasia: a histopathologic and statistical analysis |
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Authors: | C P Crum K Egawa B Barron C M Fenoglio R U Levine R M Richart |
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Institution: | 1. Department of Obstetrics/Gynecology Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, New York 10032, U.S.A.;3. Department of Surgical Pathology, Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, New York 10032, U.S.A.;2. Department of Obstetrics/Gynecology, Hiroshima University School of Medicine, Hiroshima, Japan |
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Abstract: | Two hundred fifty consecutive cases previously diagnosed as advanced intraepithelial neoplasia (CIN 2 and CIN III) were reviewed and examined for the presence of coexisting condyloma. When the mean ages and age distributions were analyzed, there was a consistent shift of the age distribution to a younger age among women with CIN and condyloma as opposed to CIN alone. Furthermore, when the relationship between age and case accumulation was normalized from a curvilinear to a linear relationship, there were significant differences in the slope of the accumulation rate between cohorts of CIN III with and without condyloma. These differences suggest that the concordant observation of both lesions in a given patient is not a random process resulting from two independent events but rather indicates an underlying dependence between the two (i.e., condyloma and CIN). It cannot, however, be determined statistically whether the associated condyloma is directly responsible for the CIN lesion or hastens its transit time. |
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Keywords: | To whom all requests for reprints should be sent |
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