AT1-受体自身抗体与原发性高血压的关系

目的 :了解AT1 受体自身抗体与原发性高血压临床特征及降压疗效的相关性 ;方法 :记录 1 2 3例原发性高血压患者多项临床资料及检测AT1 受体自身抗体 ,在抗体阳性组及阴性组中各随机抽取 2 4例患者分别给予科素亚治疗 1 2周 ,比较两组治疗前后血压变化。结果 :阳性组年龄显著高于阴性组 (P =0 .0 2 3)。Logistic回归分析表明仅年龄进入回归方程。抗体阳性组与阴性组科素亚降压疗效比较无差异 (P >0 .0 5 )。结论 :AT1 受体抗体的阳性率仅与年龄相关 ,在体内可能无明显血管活性作用

AT1 receptor autoantibodies and essential hypertension

Objective To observe the relationship between AT 1 receptor autoantibodies and clinical features in essential hypertension,and to compare the therapeutic effect of losartan between the positive and the negative group. Methods Clinical data were collected in patients with essential hypertension ( n =123). AT 1 receptor autoantibodies were checked. Twenty four patients from either AT 1 positive or AT 1 negative group were treated with losartan for 12 weeks. Results The average age in the positive group was significantly higher than that of the negative one (P=0.023). Logistic regression analysis indicated that age was an independant risk factor of AT 1 receptor autoantibody. Antihypertensive efficiency of losartan showed no obvious difference between the two groups. Conclusion Positive response of AT 1 receptor autoantibody is related only to age. Anti hypertensive therapy with losartan in the positive group shows no advantage over the negative one, indicating that AT 1 receptor autoantibodies possibly have no vascular activity in vivo