仙龙胶囊治疗血管性痴呆的临床观察

目的：探讨仙龙胶囊治疗血管性痴呆（vascular dementia,VD)的疗效机制；方法：对采用随机双盲双模拟法给药治疗的老年VD患者（仙龙胶囊组35例，喜得镇组33例）进行与学习记忆相关的胆碱能系统、氧自由基、一氧化氮（NO）方面的指标检测，并与正常组对照观察。结果：仙龙胶囊可以降低乙酰胆碱酯酶（AchE)活性，升高RBC和血浆乙酰胆碱（Ach)含量；增强红细胞超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GSH-Px）活性，降低体内脂质过氧化物（LPO）含量；抑制患者体内一氧化氮合酶（NOS）活性，降低NO含量；并且尚未发现明显毒副作用，结论：仙龙胶囊治疗老年VD疗效肯定，其机理与增强VD患者胆碱能神经系统功能，改善氧自由基代谢，调节NO功能，减轻其兴奋性神经毒性有关。

Clinical Observation on Effect of Xianlong Capsule in Treating Vascular Dementia

Objective: To study the effect of Xianlong Capsule (XLC) in treating vascular dementia (VD) and to explore its therapeutic mechanism. Methods: The criteria of learning and memory related cholinergic nerve system, oxygen free radical and nitrogen monoxide (NO) in 35 patients with VD treated with XLC and 33 patients treated with hydergine were observed and compared with the normal control group. Results: XLC could lower the acetylcholine esterase activity, increase the acetylcholine content in erythrocytes and plasma and decrease the NO content. No toxic adverse reaction was found in the observation period. Conclusion: XLC has definite effect in treating VD in aged patients, the therapeutic mechanism may be related with the actions in strengthening cholinergic nerve system, improving oxygen free radical metabolism, regulating NO and relieving its excitatory neurotoxicity.