Platelets,acute inflammation and inflammatory mediators |
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Authors: | S. H. Ferreira F. B. Ubatuba J. R. Vane |
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Affiliation: | (1) Department of Pharmacology, Faculty of Medicine of Ribeirão Prêto, São Paulo, Brazil;(2) The Wellcome Research Laboratories, Langley Court, Beckenham, Kent, England |
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Abstract: | The anti-inflammatory activity of aspirin-like drugs could derive, at least in part, by inhibiting synthesis and release of prostaglandins or rabbit aorta-contracting substance from platelets. Indeed, aggregation of platelets and the consequent release of inflammatory mediators has been frequently evoked as a factor in the development of the inflammatory reaction. The participation of platelets in acute inflammation was tested in three types of trauma in rats rendered thrombocytopenic with anti-platelet serum. Oedema in response to carrageenin, anti-platelet serum or passive cutaneous anaphylaxis was no different from the controls in thrombocytopenic rats. |
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