阿奇霉素治疗小儿支原体肺炎42例疗效观察

目的:探讨阿奇霉素治疗小儿支原体肺炎的疗效及不良反应.方法:将84例小儿支原体肺炎患儿随机分为治疗组和对照组各42例,治疗组应用阿奇霉素10 mg/(kg·d)静脉滴注,1次/d,5～7d后改用口服阿奇霉素序贯治疗,总疗程为3～4周；对照组应用红霉素20～30 mg/( kg·d)静脉滴注,2次/d,7～14 d后改用罗红霉素口服序贯治疗7～14d.治疗期间停用其他抗生素,比较两组临床疗效和临床症状、体征消失时间及不良反应.结果:治疗组和对照组总有效率分别为97.62％和95.24％,两组比较差异无统计学意义(P＞0.05)；治疗组主要临床症状、体征消失时间及平均住院时间均较对照组缩短,差异有统计学意义(P＜0.05)；治疗组的胃肠道反应、局部静脉疼痛等不良反应明显发生率低于对照组(P＜0.05).结论:阿奇霉素治疗小儿支原体肺炎具有起效快、疗效好、不良反应少等优点,是治疗小儿支原体肺炎的理想药物.

The Efficacy of Azithromycin on 42 Children with Mycoplasma Pneumonia

Objective: To investigate the efficacy and side effects of azithromycin in children with mycoplasma pneumonia.Methods: Totally 84 children with mycoplasma pneumonia were randomly divided into therapeutic and control group(42 patients in each group).Children in therapeutic group were treated with azithromycin intervenously 10 mg/(kg·d),once a day for 5~7 days,followed by oral azithromycin at the same dosage,with a total cause of 3~4 weeks;while the patients in control group were treated with erythromycin intervenously 20~30 mg/(kg·d),twice a day for 7~10 days,followed by oral erythromycin at the same dosage for another 7~14 days.Other antibiotics were not used during observation.The total efficacy and disappearance time of clinical symptom and sign,and the side effects were observed.Results: The total effective rates in the therapeutic group and the control group were 97.62% and 95.24% respectively,and there was no significant difference group(P>0.05).The disappearance time of clinical symptom,sign and the duration of hospitalization were shorter in the therapeutic group than those in the control group(P<0.05).The ratio of adverse reactions such as gastrointestinal reaction,local intravenous pain in azithromycin treatment group were significantly lower than those in the control group(P<0.05).Conclusions: Azithromycin is more fast-acting,more effective and safer in the treatment of mycoplasma pneumonia in children than erythromycin.Azithromycin is promising in the treatment of children with mycoplasma pneumonia.