大剂量氨溴索防治早产儿呼吸窘迫综合征疗效观察

目的:观察应用大剂量氨溴索对早产儿呼吸窘迫综合征(NRDS)的防治效果。方法:随机将85例早产儿分为治疗组41例及对照组44例,在相同综合治疗基础上,治疗组加用氨溴索30 mg/(kg.d),连用5 d,观察患儿的生命体征及转归,总结NRDS发生率及使用呼吸机的情况,并对相关指标进行统计学分析。结果:治疗组中13例(31.71%)应用了新型鼻塞式持续气道正压通气(NCPAP),6例(14.63%)出现NRDS,上机率12.19%;对照组23例(52.27%)使用了NCPAP,15例(34.09%)发生NRDS,上机率29.55%。两组患儿上机后6 h、48 h的血气分析比较,PaO2、pH差异无统计学意义(P>0.05),PaCO2、PaO2/FiO2、RI及通气时间、住院天数比较差异均有统计学意义(P<0.05)。两组患儿除肺部感染差异有统计学意义外(P<0.05),其余并发症差异无统计学意义。结论:应用大剂量氨溴索有助于减少NRDS的发生,降低上机率,防治轻度NRDS。

Therapeutic Effect of Ambroxol on Neonatal Respiratory Distress Syndrome

Objective:To evaluate the effect of large dosage ambroxol in the prevention and treatment of neonatal respiratory distress syndrome(NRDS).Methods:Randomly 85 newborns were divided into treatment group(41 cases) and control group(44 cases).Besides the routine treatment,the treatment group were given ambroxol 30 mg/(kg·d) for 5 days additionally,and the control group was not given the intervention.The incidence of NRDS and mechanical ventilation(MV)were observed,and other indicators were statistically analyzed.Results:In the treatment group,13 cases used new nasal continuous positive airway pressure-type(NCPAP),6 cases were diagnosed as NRDS,and 5 infants needed MV.The incidence was respectively 31.71%,14.63%,12.19%.In the control group,NCPAP was applied to 23 infants,15 infants were diagnosed as NRDS,13 cases needed MV.The morbidity was separately 52.27%,34.09%,29.55%.PaCO2,PaO2/FiO2 and RI were significantly different between the two groups after 6 h and 48 h MV(P<0.01),but PaO2 and pH had no difference(P>0.05).The time of ventilation and hospitalization had obvious change(P<0.05),and the rate of pulmonary infection in the treatment group was less than that in the control group(P<0.01).Conclusions:Large dose of ambroxol can significantly reduce the morbidity of NRDS and the rate of MV.It can effectively prevent and treat NRDS.