间苯三酚注射液治疗婴幼儿秋季腹泻的临床观察

目的:探讨间苯三酚注射液治疗婴幼儿秋季腹泻的临床疗效。方法:80例秋季腹泻患儿随机分为对照组和治疗组各40例。对照组给予常规治疗,治疗组在常规治疗基础上肌肉注射或静脉滴注间苯三酚注射液20 mg/次,2次/d,疗程3～5d。结果:治疗组总有效率77.5%,比对照组47.5%高,差异有统计学意义(P<0.05);治疗组治疗后3 d内大便次数平均每天为(4.6±1.6)次,对照组平均每天为(8.0±2.2)次,两组比较差异有统计学意义(P<0.01);治疗组血Na+、K+、HCO3-浓度均较对照组高,差异有统计学意义(P<0.05);腹泻持续时间治疗组为(118.5±25.7)h,对照组为(122.4±25.6)h,两组比较差异无统计学意义(P>0.05)。结论:间苯三酚注射液治疗小儿秋季腹泻疗效确切,能有效缓解腹泻症状,减轻水、电解质及酸碱平衡紊乱。

Clinical Observation of the Phloroglucinol Injection in Treatment of Infantile Autumn Diarrhea

Objective: To observe the effect of phloroglucinol injection in clinical treatment of infantile autumn diarrhea.Methods: Eighty infants with autumn diarrhea were randomly divided into two groups,the therapy group(n=40) and the control group(n=40).The control group was given conventional therapy.On the basis of the conventional therapy,the therapy group was given phloroglucinol injection by muscular injection or intravenous drip,20 mg,twice a day,3~5 days treatment course.Results: In the therapy group,the total efficiency was 77.5%,while that in the control group was 47.5%,the difference was statistically significant(P<0.05).After treatment for 3 days,stool frequency in the therapy group were(4.6±1.6) times a day,while that in the control group were(8.0±2.2) times a day,the difference was statistically significant(P<0.01).Blood sodium,potassium,and bicarbonate in the therapy group were higher than those in the control group;the difference was statistically significant(P<0.05).Duration of diarrhea in the therapy group were(118.5±25.7) hours,while that in the control group were(122.4±25.6) hours;two groups had no significant difference(P>0.05).Conclusions: Phloroglucinol injection in the treatment of infantile autumn diarrhea is curative effect,which can effectively alleviate the symptoms of diarrhea,reduce water,electrolyte and acid-base balance disturbance.