细菌溶解产物治疗儿童缺铁性贫血伴反复呼吸道感染的疗效观察

目的:观察轻中度缺铁性贫血(IDA)伴反复呼吸道感染(RRI)儿童服用细菌溶解产物(泛福舒)的临床疗效及安全性.方法:采用随机法将68例轻中度IDA伴RRI患儿分为两组,A组35例,口服铁剂同时口服泛福舒,B组33例,仅口服铁剂治疗,观察两组患儿的临床症状、血清免疫球蛋白IgA、IgG、IgM和血红蛋白(HB)水平及可能出现的不良反应.结果:A组治疗后血清IgA、IgG及HB水平比治疗前显著升高(P＜0.05或P＜0.01),IgM与治疗前比较差异无统计学意义(P＞0.05)；B组治疗后IgA、IgG、IgM与治疗前比较差异均无统计学意义(P均＞0.05),HB水平有所升高,但差异无统计学意义(P＞0.05)；与B组比较,A组呼吸道感染次数、发热天数、抗生素使用天数、咳嗽天数均减少,差异均有统计学意义(P＜0.01或P＜0.05).结论:IDA合并RRI经口服铁剂治疗不理想儿童联用泛福舒能有效减少RRI的发生,较快纠正贫血.泛福舒安全性好,使用方便,值得推广.

Effect Observation of Bacterial Lysates in the Treatment of Iron Deficiency Anemia and Recurrent Respiratory Infections in Children

Objective: To observe the clinical curative effect and safety of bacterial lysates(Broncho-Vaxom) in children with mild to moderate iron deficiency anemia(IDA) and recurrent respiratory infections(RRI).Methods: Randomly 68 patients with mild to moderate IDA and RRI were divided into two groups.In Group A,35 patients were treated with peros chalybeate and Broncho-Vaxom;in Group B,33 patients only received chalybeate in order to observe the level of clinical symptom,serum immune globulin IgA,IgG,IgM and hemoglobin,as well as the possible adverse effect.Results: After the treatment,the levels of serum IgA,IgG and HB in group A raised significantly than those in pretherapy(P<0.05 or P<0.01),while,no difference in IgM,compared with those in pretherapy,was significant(P>0.05).In group B,compared with the pretherapy,there was no significant differences in IgA,IgG and IgM(all P>0.05).Although the level of HB increased,there was no statistical difference,either(P>0.05).Compared with group B,the frequency of respiratory infection and days of febricity,antibiotics use and cough in group A were reduced and had statistical significance(P<0.01 or P<0.05).Conclusions: For the children with IDA and RRI,the combination of Broncho-Vaxom and chalybeate can decrease RRI incidence and cure anemia effectively.Broncho-Vaxom is safe and convenient.