奥美拉唑治疗新生儿应激性溃疡临床疗效观察

目的:探讨奥美拉唑治疗新生儿应激性溃疡的临床疗效。方法:将56例患应激性溃疡的新生儿随机分为治疗组30例和对照组26例,在综合治疗基础上,治疗组静脉注射奥美拉唑0.5～0.8 mg/(kg.d),1次/d,对照组给予去甲肾上腺素0.4 mg+NS 10 mL胃管内注入,每6 h一次,比较两种方法治疗新生儿应激性溃疡的疗效。结果:治疗组总有效率80.0%,对照组总有效率42.3%,两组比较差异有统计学意义(P<0.01)。治疗组循环不良消失、胃肠功能紊乱消失、意识恢复、神经反射恢复及肌张力恢复时间均短于对照组,差异均有统计学意义(P<0.05)。结论:奥美拉唑治疗新生儿应激性溃疡疗效显著,未见明显不良反应发生。

Effect Comparison of Omeprazole and Norepinephrine in Treating Ulcer Hemorrhage in the Newborn

Objective: To observe the efficacy of omeprazole in treating stress ulcer hemorrhage in the newborn.Methods: Together 56 patients were divided into two groups randomly: treatment group(n=30) and control group(n=26).Besides the combined treatment,treatment group were given omeprazole injection,0.5~0.8 mg/(kg·d),while control group received norepinephrine 0.4 mg + NS 10 mL injected into the stomach,once every 6 hours.The efficacy of two groups in treating stress ulcer hemorrhage of newborn was compared.Results: The total effective rate was 80.0% in treatment group and 42.3% in control group.There was significant difference between them(P<0.01).The disappearance time of poor circulation and gastrointestinal disorders,and the recovery time of consciousness,nerve reflex and muscle tension of the treatment group were shorter than those of the control group,the differences were statistically significant(P<0.05).Conclusions: The efficacy of omeprazole is obvious for treating stress ulcer hemorrhage in newborn.There is no obvious adverse reaction.