Prevention of diabetic glomerulopathy in streptozotocin diabetic rats by insulin treatment |
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Authors: | R Rasch |
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Institution: | (1) Second University Clinic of Internal Medicine, University Institute of Pathology, Århus Kommunehospital, Denmark;(2) Department of Cell Biology, Institute of Anatomy, University of Århus, Århus, Denmark |
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Abstract: | Summary Glomerular basement membrane thickness (GBMT) has been measured in streptozotocin diabetic rats treated with insulin. The study included 3 groups of 8 rats each: 1) a well-controlled group of diabetic rats under insulin treatment with a plasma glucose level reasonable close to normal values, 2) a poorly-controlled group also under insulin treatment with constant high plasma glucose values, and 3) an age and weight matched non-diabetic control group. After 6 months of diabetes, GBMT was measured applying an intercept method on 3 glomerular cross sections from each of the 24 animals. The measurements showed that mean GBMT was 132.2. nm in the non-diabetic control rats and 131.6 nm in the well-controlled diabetic rats. In the poorly-control-led group the mean GBMT was 140.4 nm, i.e. statistically significantly increased when compared to each of the two other groups, 2p=0.022 and 0.012 respectively.The results demonstrate that good blood glucose control in rats preserves normal GBMT. |
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Keywords: | Glomerular basement membrane streptozotocin diabetes glucose control in rats diabetic glomerulopathy stereology membrane thickness |
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