Long-term outcome in aqueductal stenosis |
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Authors: | Roberto Villani Giustiro Tomei Sergio M. Gaini Nadia Grimoldi Diego Spagnoli Lorenzo Bello |
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Affiliation: | (1) Institute of Neurosurgery, The University of Milan, Ospedale Maggiore Policlinico, 35, F. Sforza Str., I-20122 Milan, Italy |
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Abstract: | In this study, 78 patients with aqueductal stenosis were submitted to detailed neurodevelopmental assessment with a follow-up of 5–25 years. Sixty-eight percent of patients were categorized as normal; they either attended normal school courses or had regular jobs. Among these, 34% had some motor abnormalities (ataxia, mild hemiparesis, visual disturbances). Twenty-four percent (19 cases) were moderately disabled (trainable retardation) and 8% (6 cases) were severely handicapped. Epilepsy was observed in 13% of the cases. Incidence of recurrent and generalized seizures paralleled neurodevelopmental outcome (5% in normal, 16% in moderately disabled and 50% in severely disabled patients). Endocrine dysfunctions were evident in 28% of the cases and were characterized by precocious or delayed puberty, amenorrhea and somatic underdevelopment. No patient with ventricular enlargement and a cortical mantle width below 20 mm showed a good outcome. Large ventricles were compatible with normal mental development when compensated with a corresponding cranial vault enlargement. In patients with normal mental status and motor abnormalities, longterm CT scan findings revealed the presence of focal brain abnormalities (poroencephaly, brain atrophy, calcifications, extracerebral collections).Presented at the Consensus Conference: Hydrocephalus '92, Assisi, Italy, 26–30 Aprill 1992 |
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Keywords: | Hydrocephalus Aqueductal stenosis Outcome |
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