埃索美拉唑锌固体分散体的制备及其体外溶出特性

目的通过制备成固体分散体的方法提高埃索美拉唑锌的溶出度。方法以聚乙烯吡咯烷酮K30(PVPK30)和聚乙二醇6000(PEG 6000)为载体,采用溶剂法将埃索美拉唑锌制备成固体分散体,然后将所得固体分散体装填于肠溶胶囊,并考察其在人工肠液中的溶出特性;利用差示扫描量热分析(DSC)鉴别埃索美拉唑锌在固体分散体中的存在状态。结果随着载体比例增加,固体分散体体外溶出度先增大后减小;以PEG 6000为载体制备的固体分散体溶出度优于以PVPK30制备的固体分散体;DSC分析表明,埃索美拉唑锌在以PEG 6000为载体制备的固体分散体中以非晶型存在。结论固体分散体提高了埃索美拉唑锌的体外溶出速度。

Preparation and Dissolution in vitro of Esomeprazole Zinc Solid Dispersion

Objective To prepare esomeprazole zinc solid dispersion(EZSD)to improve its dissolution in vitro.Methods EZ solid dispersions were prepared by solvent method using PVP K30 and PEG 6000 as carriers.The in vitro dissolution of the EZ solid dispersions enteric capsules was analyzed.The existence status of EZ in the carrier was determined by differential scanning calorimeter(DSC).Results The dissolution of EZ increased first and then decreased with the increase of the ratio of carries.The dissolution of the solid dispersions with PEG 6000 as carrier was faster than that with PVP K30 as carrier.The EZ was amorphously dispersed in the solid dispersion.Conclusion The in vitro dissolution rate of EZ is significantly improved by the solid dispersion.