Blood CD34-c-Kit+ cell rate correlates with aggressive forms of systemic mastocytosis and behaves like a mast cell precursor |
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Authors: | Georgin-Lavialle Sophie Lhermitte Ludovic Baude Cédric Barete Stéphane Bruneau Julie Launay Jean-Marie Chandesris Marie-Olivia Hanssens Katia de Gennes Christian Damaj Gandhi Lanternier Fanny Hamidou Mohamed Lortholary Olivier Dubreuil Patrice Feger Frédéric Lepelletier Yves Hermine Olivier |
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Affiliation: | Service d'Hématologie Adultes et Centre de Référence sur les Mastocytoses, H?pital Necker-Enfants Malades, Université Paris Descartes, Assistance Publique-H?pitaux de Paris, France. ohermine@gmail.com |
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Abstract: | Mastocytosis is a heterogeneous disease characterized by the accumulation of mast cells in one or more organs. Our objective was to identify a peripheral mast cell precursor and assess its variation rate in mastocytosis. A peripheral blood phenotypic analysis was performed among 50 patients with mastocytosis who were enrolled in a prospective multicentric French study, and the phenotypic analysis results of the patients were compared with those of healthy donors. The rate of peripheral blood CD34(-)c-Kit(+) cells correlated with the severity of mastocytosis. This cellular population was isolated from healthy donors as well as from patients with systemic mastocytosis. After 30 days of culture, the CD34(-)c-Kit(+) cells gave birth to mature mast cells, indicating that this cellular population constitutes a mast cell circulating precursor. Monitoring peripheral CD34(-)c-Kit(+) cells by flow cytometry could be a useful and low-invasive tool to determine the disease severity and the relapses and to assess treatment efficiency. |
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