Familial PRRT2 mutation with heterogeneous paroxysmal disorders including paroxysmal torticollis and hemiplegic migraine |
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| Authors: | Russell C Dale Alice Gardiner Jayne Antony Henry Houlden |
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| Institution: | Movement Disorder Clinic, Institute of Neuroscience and Muscle Research, Children's Hospital at Westmead, Sydney, NSW, Australia. MRC Centre for Neuromuscular Diseases and Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK. T.Y. Nelson Department of Neurology and Neurosurgery, Children's Hospital at Westmead, Sydney, NSW, Australia. |
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| Abstract: | PRRT2 is the gene recently associated with paroxysmal kinesigenic dyskinesia (PKD), benign familial infantile epilepsy, and choreoathetosis infantile convulsions. We report four family members with PRRT2 mutations who had heterogeneous paroxysmal disorders. The index patient had transient infantile paroxysmal torticollis, then benign infantile epilepsy that responded to carbamazepine. The index patient's father had PKD and migraine with aphasia, and his two brothers had hemiplegic migraine with onset in childhood. All four family members had the same PRRT2 c.649dupC mutation. We conclude that heterogeneous paroxysmal disorders are associated with PRRT2 mutations and include paroxysmal torticollis and hemiplegic migraine. We propose that PRRT2 is a new gene for hemiplegic migraine. |
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