丹参桃芎汤对肝纤维化小鼠腹膜淋巴孔的调控与尿钠离子浓度变化的影响

目的寻找治疗肝硬变腹水的有效方药.方法具有腹膜淋巴孔调控作用的丹参配合活血化瘀的桃仁、川芎组成丹参桃芎汤对肝纤维化造模小鼠进行腹膜淋巴孔调控与尿离子浓度变化的实验,并经扫描电镜和计算机图像处理与定量分析.结果预防组、治疗组腹膜淋巴孔孔径、密度与模型组、对照组比较有非常显著性差异(P＜0.001),而尿离子测定,治疗组不及预防组.结论丹参桃芎汤是治疗腹水的有效方剂.

Experimental Study on Effect of Danshen Tao Xiong Decoction on the Peritoneal Lymphatic Stomata and Urinary Sodium in Hepatic Fibrosis Mice

Aim: To find effective drug treating hepatic fibrosis ascites. Methods: Danshen Tao Xiong Decoction (DSTXU) Composed of Radix Salviae Miltiorrhizae has effect on the regulation of the peritoneal lymphatic stomata, Semen Persicae and Rhizoma Ligustici Chuanxiong providing with promoting blood circulation to remove blood stasis, was used in the research of the peritoneal lymphatic stomata and urinary sodium in hepatic fibrosis mice. The diameter and distributive density of the peritoneal lymphatic stomata were quantitatively analysed by using scanning electron microscope and computer image system. Results :The diameter and distributive density were more obvious in prevention and treatment groups than the control and model groups. Urinary sodium in prevention group drain more than that in treatment group. Conclusion: DSTXD is an effective formula for the treatment of ascites.