生脉散注射液与黄芪注射液对冠心病伴左心功能不全的疗效比较

目的：观察生脉散注射液与黄芪注射液对冠心病伴左心功能不全（ＬＶＤ）的疗效比较。方法：冠心病伴ＬＶＤ５１例。生脉散组３２例，给生脉散注射液８支（１０ｍＬ／支）加入１０％葡萄糖注射液５００ｍＬ静脉滴注（静滴），ｑｄ；黄芪对照组１９例，应用黄芪注射液６支（２ｍＬ／支）加入１０％葡萄糖注射液５００ｍＬ静滴，ｑｄ，２组均用药１４ｄ。结果：生脉散不仅能改善左室收缩功能（ＳＶ，ＣＯ，ＣＩ，ＦＳ，ＥＦ）（Ｐ＜０．０１），对舒张功能也有显著的疗效（ＰＥ，ＥＳ，ＰＥ／ＰＡ）（Ｐ＜０．０１）。临床无明显不良反应。而黄芪注射液仅对左心收缩功能（ＣＯ，ＣＩ，ＦＳ，ＥＦ）有改善（Ｐ＜０．０１或Ｐ＜０．０５）。结论：生脉散注射液治疗冠心病伴ＬＶＤ疗效优于黄芪注射液。

Effect of Sheng_mai_san injection vs Astragalus membranaceus injection in treating coronary heart disease with left ventricular dysfunction

AIM: To observe Sheng_mai_san injection (containing radix ginseng rubra, Ophiopogon japonicus, Schisandra Chinensis) vs Astragalus membranaceus injection in treating coronary heart disease (CHD) with left ventricular dysfunction (LVD). METHODS: Thirty_two CHD patients (M 14, F 18, age: 66±s 11 a) with LVD were treated with Sheng_mai_san injection 80 mL in 10% glucose 500 mL, iv, drip, qd for 2 wk. Nineteen CHD patients (M 8, F 11, age 63±11 a) with LVD were treated with Astragalus membranaceus injection 12 mL in 10% glucose 500 mL iv, drip, qd for 2 wk. Before and after treatments cardiac function was assessed by pulsed Doppler echocardiography. Sheng_mai_san injection was compared with Astragalus membranaceus injection. RESULTS: Sheng_mai_san injection group showed left ventricular systolic function (SV, CO, CI, EF and FS) and left ventricular diastolic function parameters (PE, ES, PE/PA) were improved (P<0.01). Left ventricular systolic function parameters (CI, CO, FS, EF) of Astragalus membranaceus injection group were also improved (P<0.05, P<0.01), but the drug had no effects on left ventricular diastolic function. Adverse reaction was not found in Sheng_mai_san injection group. CONCLUSION: The effects of Sheng_mai_san injection is superior to the Astragalus membranaceus injection for treatment on coronary heart disease with LVD.