| 普伐他汀与多烯康治疗高脂血症的疗效比较 |
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| 引用本文： | 陈寿生,王宇森,李瑞芬,胡铭芬,陈佳和,潘佩文. 普伐他汀与多烯康治疗高脂血症的疗效比较[J]. 中国新药与临床杂志, 1998, 17(5): 269-273 |
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| 作者姓名： | 陈寿生 王宇森 李瑞芬 胡铭芬 陈佳和 潘佩文 |
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| 作者单位： | 上海市卢湾区中心医院内科 |
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| 摘 要： | 目的：比较普伐他汀与多烯康治疗高脂血症的疗效与安全性。方法：高脂血症６０例，随机分为２组。普伐他汀组３０例（男性１６例，女性１４例；年龄５８±ｓ１１ａ）采用普伐他汀１０～２０ｍｇ，ｐｏ，ｑｎ×６ｍｏ；多烯康组３０例（男性１８例，女性１２例；年龄６０±１０ａ）采用多烯康胶丸３粒（０．４５ｇ／粒），ｐｏ，ｔｉｄ×６ｍｏ。结果：普伐他汀组总胆固醇、三酰甘油、低密度脂蛋白胆固醇均显著下降（Ｐ＜０．０１），总有效率依次为９０％，５３％，９３％；多烯康组下降均不显著；２组均无明显不良反应。结论：普伐他汀为一安全的、且降脂疗效优于多烯康的药物。
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| 关 键 词： | 普伐他汀；多烯康；高脂血症；鱼油 |
Pravastatin vs Duo-xi-kang in treating hyperlipidemia |
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| CHEN Shou_Sheng,WANG Yu_Sen,LI Rui_Fen,HU Ming_Fen,CHEN Jia_He,PAN Pei_Wen. Pravastatin vs Duo-xi-kang in treating hyperlipidemia[J]. Chinese Journal of New Drugs and Clinical Remedies, 1998, 17(5): 269-273 |
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| Authors: | CHEN Shou_Sheng WANG Yu_Sen LI Rui_Fen HU Ming_Fen CHEN Jia_He PAN Pei_Wen |
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| Abstract: | AIM: To compare the effects and safety of pravastatin and Duo_xi_kang in treating hyperlipidemia. METHODS: Hyperlipidemia 60 patients were randomly divided into 2 groups. Pravastatin group of 30 patients (M 16, F 14; age 58±s 11 a) received pravastatin 10_20 mg, po, qn for 6 mo. Duo_xi_kang group of 30 patients (M 18, F 12; age 60±10 a) received Duo_xi_kang 1.35 g(0.45 g/pill)po, tid for 6 mo. RESULTS: The total effective rates for reducing total cholesterol (TC), triglycerides (TG), and low_density lipoprotein cholesterol (LDL_ch) in pravastatin group were 90%, 53%, and 93%(P<0.01), respectively. Duo_xi_kang did not produce marked change. There were no severe adverse reactions. CONCLUSION: Pravastatin is safe and effective on hyperlipidemia. |
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| Keywords: | pravastatin Duo_xi_kang hyperlipidemia fish oils |
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