高胆固醇饮食对孕鼠肾上腺束状带的影响

本文应用光镜和电镜形态计量,结合血浆皮质酮RIA等方法,探讨妊娠期间持续高胆固醇饮食15天和21天孕鼠肾上腺皮质速状带的形态和功能变化。结果表明,高胆固醇饮食虽然可引起不同时期孕鼠肾上腺相对重量、束状带体积比和束状带细胞的平均体积增加,但在本质上其效应不同。孕15天时,其线粒体和SER体密度增加,血浆皮质酮水平明显升高;而孕21天时,这些指标变化则相反。

Influence of High Cholesterol Diet on Adrenocortical Zono Fasciculata in pregnant Rat

Two groups pregnant rats were maintained on high cholesterol(HC) diet for 15 and 21 days, respectively. Their adrenocortical zono fasciculatae were studied by means of sterology combined with plasma cholesterol assay and RIA of corticosterone. The results, showed that all pregnant rats fed with HC diet were found to increase relative adrenal gland weight, density of zono fasciculata and average voluma of the cell while the blood cholesterol rose. However, on the 15th day influence of HC diet on fasciculata was different from that of the 21th day during the gestation. on the 15th day, the volume density of mitochondria and SER enlarged with parallel increase of the plasma corticosterone level, but on the 21th day these turned out to be contrary to those of the 15th day. This study suggests that HC diet induces to stimulate hyperfunction of zono fasciculate during midpregnaney, but then tends to result in hoperfunction of zono fasciulata during late pregnancy.