| 旱柳叶中抗血栓,抗动脉硬化活性成分的研究 |
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| 引用本文： | 张晶,韩立坤.旱柳叶中抗血栓,抗动脉硬化活性成分的研究[J].中药材,1999,22(3):131-133. |
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| 作者姓名： | 张晶 韩立坤 |
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| 作者单位： | 吉林农业大学中药材学院，吉林农业大学中药材学院，日本爱媛大学医学部第二教室 长春130118，长春130118 |
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| 摘 要： | 本文从早柳叶中分离并鉴定了3个单体化合物,即芹黄素-7-O-β-D-吡喃葡萄糖醛酸甙、木樨草素-7-O-β-D吡喃葡萄糖醛酸甙及化合物Ⅲ。前两者为首次从柳属植物叶片中获得,后者为首次发现的新化合物。测定它们对花生四烯酸代谢的影响,结果发现:它们均可选择性抑制花生四烯酸代谢产物12-HETE的生成量,预示它们可防治动脉硬化及过敏症;芹黄素-7-O-β-D-吡喃葡萄糖醛酸甙水解后的甙元芹黄素可抑制TXB_2的生成量,提示其对血栓的形成有防治功效。
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| 关 键 词： | 旱柳叶 芹黄素-7-O-β-D-吡喃葡萄糖醛酸甙 木樨草素-7-O-β-D-吡喃葡萄糖醛酸甙 |
Isolation of Resisting Thrombus and Arteriosclerosis Compounds in Leaves of Salix matsudana |
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| Zhang Jing,Zheng Yinan,Han Likun.Isolation of Resisting Thrombus and Arteriosclerosis Compounds in Leaves of Salix matsudana[J].Jorunal of Chinese Medicinal Materials,1999,22(3):131-133. |
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| Authors: | Zhang Jing Zheng Yinan Han Likun |
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| Institution: | College of Chinese Medicine Material, Jilin Argricultural University, Changchun 130118. |
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| Abstract: | In this paper, three compounds were isolated and identified from the leaves of Salix matsudana. They are apigenin-7-0-beta-D-glucopyranside(I), luteolin-7-0-beta-D-glucopyranside(II), compound III. Compound I and II are isolated firstly from Salix spp., compound III is found firstly in the world. Furthermore, study on effect of arachidonic acid metabolisin in rat platelets by them with radio-chromatography found that they can significantly inhibit the production of 12-HETE(12-hydroxy-5,8, 10,14-eicosatetraenoic acid), which can induce allergy and arteriosclerosis. The production of apigenin-7-0-beta-D-glucopyranside being hydrolyzed was apigenin, it can inhibit TXB2(thromoxane B2) which can induce platelet aggregation. |
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