| 新疆哈萨克族冠心病患者eNOS基因G894T多态性分析 |
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| 引用本文： | 陈春丽,江雪萍. 新疆哈萨克族冠心病患者eNOS基因G894T多态性分析[J]. 临床和实验医学杂志, 2010, 9(7): 499-501 |
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| 作者姓名： | 陈春丽 江雪萍 |
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| 作者单位： | 1. 新疆奎屯农七师医院
2. 新疆奎屯农七师疾控中心,新疆,奎屯,833200 |
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| 摘 要： | 目的探讨新疆哈萨克族人群内皮型一氧化氮合酶（eNOS）基因多态性与冠心病的相关性。方法应用聚合酶链反应（PCR）一限制性片段长度多态性分析（PCR—RFLP），检测新疆哈萨克族70例健康个体和87例冠心病患者eNOS基因G894T多态性。结果新疆哈萨克族健康个体及冠心病患者的eNOS基因G894T多态性GG、GT、Tr基因型频率分布分别为51．43％、30．00％、18．57％和24．14％、55．17％、21．69％，G和T等位基因分布频率分别为75．71％、24．29％和56．32％、43．68％，冠心病患者存在G等位基因频率下降，T等位基因频率升高趋势。结论eNOS基因G894T多态性分析，与新疆哈萨克族冠心病有相关性。
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| 关 键 词： | 冠心病 哈萨克族 内皮型一氧化氮合酶基因 基因多态性 |
Study on polymorphism of eNOS gene G894T in Kazak patients with CHD in Xinjiang |
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| CHEN Chun-li,Jiang Xue-ping. Study on polymorphism of eNOS gene G894T in Kazak patients with CHD in Xinjiang[J]. Journal of Clinical and Experimental Medicine, 2010, 9(7): 499-501 |
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| Authors: | CHEN Chun-li Jiang Xue-ping |
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| Affiliation: | CHEN Chun-li1,Jiang Xue-ping2.1 NongQiShi-Hospital of Kuitun,2 Center of Disease Control in Nongqishi Kuitun Xingjiang,Kuitun Xinjiang 833200,China |
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| Abstract: | Objective To study the relationship between coronary heart disease(CHD) and polymorphism of gene of nitric oxide synthase (eNOS G894T) in Kazaks in Xinjiang.Methods The eNOS gene related polymorphism of G894T was detected by polymerized chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 70 cases of CHD and 87 healthy subjects.Results Result of tests showed that frequencies of GG,GT and TT of eNOS gene were 51.43%,30.00%,18.57% and 24.14%,55.17%,21.69% in healthy group and CHD group respec... |
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| Keywords: | Coronary heart disease Kazak Nitric oxide synthase gene Polymorphism of gene |
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